Rapid emergence from dexmedetomidine sedation in Sprague Dawley rats by repurposing an α2-adrenergic receptor competitive antagonist in combination with caffeine

[1] Cormack JR(2005)The role of α2-agonists in neurosurgery J Clin Neurosci 12 375-378

[2] Orme RM(2013)Dexmedetomidine as a sedative agent in critically ill patients: a meta-analysis of randomized controlled trials PLoS ONE 8 e82913-1142

[3] Costello TG(2011)Dexmedetomidine in children: current knowledge and future applications Anesth Analg 113 1129-512

[4] Pasin L(2020)Activation of the α2B adrenoceptor by the sedative sympatholytic dexmedetomidine Nat Chem Biol 16 507-882

[5] Greco T(2018)Inhibitory Gi/O-coupled receptors in somatosensory neurons: potential therapeutic targets for novel analgesics Mol Pain 14 1744806918763646-32

[6] Feltracco P(2003)Early Exposure to Common Anesthetic Agents Causes Widespread Neurodegeneration in the Developing Rat Brain and Persistent Learning Deficits J Neurosci 23 876-451

[7] Vittorio A(2017)A holistic approach to anesthesia-induced neurotoxicity and its implications for future mechanistic studies Neurotoxicol Teratol 60 24-491

[8] Neto CN(2017)Dexmedetomidine: the new all-in-one drug in paediatric anaesthesia? Curr Opin Anesthesiol 30 441-e132

[9] Cabrini L(2019)Postoperative Delirium and Postoperative Cognitive Dysfunction: Overlap and Divergence Anesthesiol 131 477-820

[10] Mason KP(2020)Randomized clinical trial of intraoperative dexmedetomidine to prevent delirium in the elderly undergoing major non-cardiac surgery Br J Surg 107 e123-204

[1] Cormack JR(2005)The role of α2-agonists in neurosurgery J Clin Neurosci 12 375-378

[2] Orme RM(2013)Dexmedetomidine as a sedative agent in critically ill patients: a meta-analysis of randomized controlled trials PLoS ONE 8 e82913-1142

[3] Costello TG(2011)Dexmedetomidine in children: current knowledge and future applications Anesth Analg 113 1129-512

[4] Pasin L(2020)Activation of the α2B adrenoceptor by the sedative sympatholytic dexmedetomidine Nat Chem Biol 16 507-882

[5] Greco T(2018)Inhibitory Gi/O-coupled receptors in somatosensory neurons: potential therapeutic targets for novel analgesics Mol Pain 14 1744806918763646-32

[6] Feltracco P(2003)Early Exposure to Common Anesthetic Agents Causes Widespread Neurodegeneration in the Developing Rat Brain and Persistent Learning Deficits J Neurosci 23 876-451

[7] Vittorio A(2017)A holistic approach to anesthesia-induced neurotoxicity and its implications for future mechanistic studies Neurotoxicol Teratol 60 24-491

[8] Neto CN(2017)Dexmedetomidine: the new all-in-one drug in paediatric anaesthesia? Curr Opin Anesthesiol 30 441-e132

[9] Cabrini L(2019)Postoperative Delirium and Postoperative Cognitive Dysfunction: Overlap and Divergence Anesthesiol 131 477-820

[10] Mason KP(2020)Randomized clinical trial of intraoperative dexmedetomidine to prevent delirium in the elderly undergoing major non-cardiac surgery Br J Surg 107 e123-204