The roles of the proteasome pathway in signal transduction and neurodegenerative diseases

被引：33

作者：

Chen J.-J. ^{[1
]}

Lin F. ^{[1
]}

Qin Z.-H. ^{[1
]}

机构：

[1] Department of Pharmacology, Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine

来源：

Neuroscience Bulletin | 2008年 / 24卷 / 3期

基金：

中国国家自然科学基金;

关键词：

Neurodegenerative disease; Proteasome; Protein misfolding; Signal transduction;

D O I：

10.1007/s12264-008-0183-6

中图分类号：

学科分类号：

摘要：

There are two degradation systems in mammalian cells, autophagy/lysosomal pathway and ubiquitin-proteasome pathway. Proteasome is consist of multiple protein subunits and plays important roles in degradation of short-lived cellular proteins. Recent studies reveal that proteasomal degradation system is also involved in signal transduction and regulation of various cellular functions. Dysfunction or dysregulation of proteasomal function may thus be an important pathogenic mechanism in certain neurological disorders. This paper reviews the biological functions of proteasome in signal transduction and its potential roles in neurodegenerative diseases. © 2008 Shanghai Institutes for Biological Sciences, CAS and Springer-Verlag GmbH.

引用

页码：183 / 194

页数：11

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