YC-1-like potentiation of nitric oxide-dependent activation of soluble guanylate cyclase by adrenochrome

被引：0
作者：
Severina I.S. [1 ]
Pyatakova N.V. [1 ]
Shchegolev A.Y. [1 ]
Sidorova T.A. [2 ]
机构：
[1] Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow 119121
[2] Blokhin Cancer Center, Russian Academy of Medical Sciences, Moscow 115478
来源：
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry | 2009年 / 3卷 / 1期
基金：
俄罗斯基础研究基金会;
关键词：
Adrenochrome; Guanylate cyclase; Nitric oxide (NO);
D O I：
10.1134/S1990750809010053
中图分类号：
学科分类号：
摘要：
The influence of adrenochrome and YC-1 activation of human platelet soluble guanylate cyclase was investigated. Adrenochrome (0.1-10.0 μM) had no effect on the basal activity, but it potentiated in a concentration-dependent manner the spermine NONO-induced activation of this enzyme. Adrenochrome also sensitized guanylate towards nitric oxide (NO) and produced the leftward shift of the spermine NONO concentration response curve. Addition of adrenochrome decreased the YC-1-induced leftward shift of the spermine NONO concentration response curve. Adrenochrome also inhibited enzyme activation byYC-1. Thus, synergistic activation of NO-stimulated guanylate cyclase activity by adrenochrome represents a new biochemical effect of this compound and indicates that adrenochrome may act as an endogenous regulator of the NO-dependent stimulation of soluble guanylate cyclase. This new property of adrenochrome, similar to YC-1 but more effective, should be taken into consideration especially under conditions of adrenochrome overproduction in the body. © Pleiades Publishing, Ltd. 2009.
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页码：44 / 47
页数：3
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