Beginning with a reflection on ‘conceptual schemes’ and ‘very’ ideas and proceeding to examine different approaches to thinking philosophy of science not only with Kant but also between traditional analytic and hermeneutico-phenomenological approaches, this essay features a review of Kant’s 1755 solar nebular hypothesis and a reading of Nietzsche and Kant on cosmology along with a reflection on chemistry and the properties of cinnabar. Overall it is argued that a philosophy of science must be critical rather than normative/prescriptive. Seeking to raise the question of science along with the question of truth (via Nietzsche and Kant), the essay also raises the question of esoteric historiography in science, including alchemy.