The effect of nitric oxide in testicular ischemia-reperfusion injury

被引：22

作者：

Barlas M. ^{[1
]}

Hatiboğlu C. ^{[1
]}

机构：

[1] Department ofPediatric Surgery, University ofAnkara, School of Medicine, Ankara

来源：

International Urology and Nephrology | 2002年 / 34卷 / 1期

关键词：

Ischemi-reperfusion injury; Nitric oxide; Testis;

D O I：

10.1023/A:1021311029572

中图分类号：

学科分类号：

摘要：

This experiment was carried out to investigate the effect of endogenous nitric oxide (NO) on the ischemia-reperfusion injury of testis. Testicular ischemia was achieved by twisting the right testis and spermatic cord 1080 counter-clockwise for 30 minutes and reperfusion was allowed for 30 minutes after detorsion of 33 rats. Animals were treated with normal saline in controls just before detorsion, NG-nitro-L-arginine methyl ester (L-NAME), and L-arginine (L-arg) in others. The tissue damage was evaluated with light microscopy, malondialdehyde (MDA) level in tissue, and the blood flow measurement using 133xenon (Xe) clearance technique. MDA indicator of reperfusion injury increased 25% after detorsion when only normal saline was given, L-NAME further increased MDA, L-arginin decreased MDA to control level. Conclusion: L-arginin infusion during the detorsion reduced the reperfusion injury of testis and improved the testicular blood flow after the detorsion.

引用

页码：81 / 86

页数：5

共 21 条

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