The Applicability of Amide Proton Transfer Imaging in the Nervous System: Focus on Hypoxic-Ischemic Encephalopathy in the Neonate

被引:0
作者
Yang Zheng
Xiaoming Wang
机构
[1] Shengjing Hospital of China Medical University,Department of Radiology
来源
Cellular and Molecular Neurobiology | 2018年 / 38卷
关键词
Neonatal; Hypoxic-ischemic encephalopathy; Magnetic resonance imaging; Amide proton transfer; pH-sensitive; Protein;
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学科分类号
摘要
In recent years, magnetic resonance imaging (MRI) has become more widely used in neonatal hypoxic-ischemic encephalopathy (HIE), involving, for example, evaluation of cerebral edema, white matter fiber bundle tracking, cerebral perfusion status, and assessment of brain metabolites. MRI has many imaging modalities. However, its application for assessing changes in the internal environment at the tissue and cellular level after hypoxia–ischemia remains a challenge and is currently the focus of intense research. Based on the exchange between amide protons of proteins and polypeptides and free water protons, amide proton transfer (APT) imaging can display changes in pH and protein concentrations in vivo. This paper is a review of the principles of APT imaging, with a focus on the potential application of APT imaging for neonatal HIE.
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页码:797 / 807
页数:10
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