Evidence on the association between NQO1 Pro187Ser polymorphism and breast cancer risk in the current studies: a meta-analysis

被引：0
作者：
Weiguang Yuan
Lidan Xu
Wangyang Chen
Lihong Wang
Zhenkun Fu
Da Pang
Dianjun Li
机构：
[1] Harbin Medical University,Institute of Cancer Prevention and Treatment
[2] Harbin Medical University,Department of Immunology
[3] Harbin Medical University,Laboratory of Medical Genetics
[4] The Third Affiliated Hospital of Harbin Medical University,Department of Surgery
来源：
Breast Cancer Research and Treatment | 2011年 / 125卷
关键词：
NQO1; SNP; Breast cancer; Meta-analysis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Several molecular epidemiological studies were conducted in recent years to evaluate the association between NQO1 Pro187Ser polymorphism and breast cancer risk in diverse populations. However, the results remain conflicting rather than conclusive. This meta-analysis on 3177 cases with breast cancer and 4038 controls from seven published case–control studies showed that the 187Ser allele was not associated with a significantly increased risk of breast cancer (Ser versus Pro: P = 0.33, OR = 1.08, 95% CI = 0.92–1.28; Ser/Ser versus Pro/Pro: P = 0.58, OR = 1.16, 95% CI = 0.68–2.00; Ser/Ser versus Pro/Ser + Pro/Pro: P = 0.62, OR = 1.14, 95% CI = 0.68–1.90; Ser/Ser + Pro/Ser versus Pro/Pro: P = 0.30, OR = 1.07, 95% CI = 0.94–1.22). In the stratified analysis by ethnicity, we found that the Pro187Ser polymorphism was associated with increased breast cancer risk in Caucasians in the additive genetic model and dominant genetic model (P = 0.03, OR = 1.13, 95% CI = 1.01–1.26; P = 0.03, OR = 1.15, 95% CI = 1.01–1.30, respectively), whereas no significant in Asians (P = 0.44, OR = 0.94, 95% CI = 0.80–1.10) and postmenopausal women (P = 0.99, OR = 1.00, 95% CI = 0.84–1.19). The results suggest that NQO1 Pro187Ser polymorphism may contribute to breast cancer development in Caucasians.
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页码：467 / 472
页数：5
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  • [21] Hunter DJ(2004)Association of NQO1 polymorphism with spontaneous breast cancer in two independent populations Br J Cancer 90 1989-1994
  • [22] Siegel D(2004)Breast cancer: role of polymorphisms in biotransformation enzymes Eur J Hum Genet 12 848-854
  • [23] Gustafson DL(2008)NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer Nat Genet 40 844-853
  • [24] Dehn DL(2003)Analysis of NQO1, GSTP1, and MnSOD genetic polymorphisms on lung cancer risk in Taiwan Lung Cancer 40 123-129
  • [25] Han JY(1995)Identification of an NAD(P)H:quinone oxidoreductase polymorphism and its association with lung cancer and smoking Pharmacogenetics 5 199-206
  • [26] Boonchoong P(2002)NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and the risk of eight cancers for Japanese Int J Clin Oncol 7 103-108
  • [27] Berliner LJ(2004)Genetic polymorphisms of MPO, COMT, MnSOD, NQO1, interactions with environmental exposures and bladder cancer risk Carcinogenesis 25 973-978
  • [28] Ross D(2007)Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers Ann Oncol 18 1230-1242
  • [29] Beyer RE(2005)Oligogenic combinations associated with breast cancer risk in women under 53 years of age Hum Genet 116 208-221
  • [30] Segura-Aguilar J(2002)Significance S-transferase M1 and NAD(P)H: quinone oxidoreductase 1 detoxification genes in breast cancer development Oncology 62 39-45
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