Evidence on the association between NQO1 Pro187Ser polymorphism and breast cancer risk in the current studies: a meta-analysis

被引：0
作者：
Weiguang Yuan
Lidan Xu
Wangyang Chen
Lihong Wang
Zhenkun Fu
Da Pang
Dianjun Li
机构：
[1] Harbin Medical University,Institute of Cancer Prevention and Treatment
[2] Harbin Medical University,Department of Immunology
[3] Harbin Medical University,Laboratory of Medical Genetics
[4] The Third Affiliated Hospital of Harbin Medical University,Department of Surgery
来源：
Breast Cancer Research and Treatment | 2011年 / 125卷
关键词：
NQO1; SNP; Breast cancer; Meta-analysis;
D O I：
暂无
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学科分类号：
摘要：
Several molecular epidemiological studies were conducted in recent years to evaluate the association between NQO1 Pro187Ser polymorphism and breast cancer risk in diverse populations. However, the results remain conflicting rather than conclusive. This meta-analysis on 3177 cases with breast cancer and 4038 controls from seven published case–control studies showed that the 187Ser allele was not associated with a significantly increased risk of breast cancer (Ser versus Pro: P = 0.33, OR = 1.08, 95% CI = 0.92–1.28; Ser/Ser versus Pro/Pro: P = 0.58, OR = 1.16, 95% CI = 0.68–2.00; Ser/Ser versus Pro/Ser + Pro/Pro: P = 0.62, OR = 1.14, 95% CI = 0.68–1.90; Ser/Ser + Pro/Ser versus Pro/Pro: P = 0.30, OR = 1.07, 95% CI = 0.94–1.22). In the stratified analysis by ethnicity, we found that the Pro187Ser polymorphism was associated with increased breast cancer risk in Caucasians in the additive genetic model and dominant genetic model (P = 0.03, OR = 1.13, 95% CI = 1.01–1.26; P = 0.03, OR = 1.15, 95% CI = 1.01–1.30, respectively), whereas no significant in Asians (P = 0.44, OR = 0.94, 95% CI = 0.80–1.10) and postmenopausal women (P = 0.99, OR = 1.00, 95% CI = 0.84–1.19). The results suggest that NQO1 Pro187Ser polymorphism may contribute to breast cancer development in Caucasians.
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页码：467 / 472
页数：5
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  • [1] Hong CC(2007)Genetic variability in iron-related oxidative stress pathways (Nrf2, NQ01, NOS3, and HO-1), iron intake, and risk of postmenopausal breast cancer Cancer Epidemiol Biomarkers Prev 16 1784-1794
  • [2] Ambrosone CB(2004)Genetic polymorphism in the manganese superoxide dismutase gene, antioxidant intake, and breast cancer risk: results from the Shanghai Breast Cancer Study Breast Cancer Res 6 R647-R655
  • [3] Ahn J(2004)Manganese superoxide dismutase polymorphism, plasma antioxidants, cigarette smoking, and risk of breast cancer Cancer Epidemiol Biomarkers Prev 13 989-996
  • [4] Choi JY(2004)NAD(P)H:quinone oxidoreductase 1: role as a superoxide scavenger Mol Pharmacol 65 1238-1247
  • [5] McCullough ML(1996)The role of DT-diaphorase in the maintenance of the reduced antioxidant form of coenzyme Q in membrane systems Proc Natl Acad Sci USA 93 2528-2532
  • [6] Stevens VL(1997)The reduction of alpha-tocopherolquinone by human NAD(P)H: quinone oxidoreductase: the role of alpha-tocopherolhydroquinone as a cellular antioxidant Mol Pharmacol 52 300-305
  • [7] Rodriguez C(2001)Relationship between NAD(P)H:quinone oxidoreductase 1 (NQO1) levels in a series of stably transfected cell lines and susceptibility to antitumor quinones Biochem Pharmacol 61 1509-1516
  • [8] Thun MJ(2009)Association between mitochondrial DNA 4, 977 bp deletion and NAD(P)H:quinone oxidoreductase 1 C609T polymorphism in human breast tissues Oncol Rep 21 1169-1174
  • [9] Calle EE(2003)Interaction of human NAD(P)H:quinone oxidoreductase 1 (NQO1) with the tumor suppressor protein p53 in cells and cell-free systems J Biol Chem 278 10368-10373
  • [10] Cai Q(2001)Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1 Proc Natl Acad Sci USA 98 1188-1193
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