Lessons from a tarantula: new insights into myosin interacting-heads motif evolution and its implications on disease

被引：30
作者：
Alamo L. [1 ]
Pinto A. [1 ]
Sulbarán G. [1 ,2 ]
Mavárez J. [3 ]
Padrón R. [1 ]
机构：
[1] Centro de Biología Estructural “Humberto Fernández-Morán”, Instituto Venezolano de Investigaciones Científicas (IVIC), Apdo. 20632, Caracas
[2] Institut de Biologie Structurale (IBS), CEA-CNRS Université Grenoble Alpes, Grenoble
[3] Laboratoire d’Ecologie Alpine, UMR 5553 CNRS-Université Grenoble Alpes, 2233 Rue de la Piscine, Grenoble
来源：
Biophysical Reviews | 2018年 / 10卷 / 5期
基金：
美国国家卫生研究院;
关键词：
Hypertrophic cardiomyopathy; Muscle disease; Muscle evolution; Myosin filaments; Myosin interacting-heads motif; Tarantula;
D O I：
10.1007/s12551-017-0292-4
中图分类号：
学科分类号：
摘要：
Tarantula’s leg muscle thick filament is the ideal model for the study of the structure and function of skeletal muscle thick filaments. Its analysis has given rise to a series of structural and functional studies, leading, among other things, to the discovery of the myosin interacting-heads motif (IHM). Further electron microscopy (EM) studies have shown the presence of IHM in frozen-hydrated and negatively stained thick filaments of striated, cardiac, and smooth muscle of bilaterians, most showing the IHM parallel to the filament axis. EM studies on negatively stained heavy meromyosin of different species have shown the presence of IHM on sponges, animals that lack muscle, extending the presence of IHM to metazoans. The IHM evolved about 800 MY ago in the ancestor of Metazoa, and independently with functional differences in the lineage leading to the slime mold Dictyostelium discoideum (Mycetozoa). This motif conveys important functional advantages, such as Ca2+ regulation and ATP energy-saving mechanisms. Recent interest has focused on human IHM structure in order to understand the structural basis underlying various conditions and situations of scientific and medical interest: the hypertrophic and dilated cardiomyopathies, overfeeding control, aging and hormone deprival muscle weakness, drug design for schistosomiasis control, and conditioning exercise physiology for the training of power athletes. © 2017, International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany.
引用
收藏
页码：1465 / 1477
页数：12
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