Anti-inflammatory treatment strategies for ischemia/reperfusion injury in transplantation

被引：0
作者：
Jens Lutz
Klaus Thürmel
Uwe Heemann
机构：
[1] Klinikum rechts der Isar,Department of Nephrology, II. Medizinische Klinik
[2] Technische Universität München,undefined
来源：
Journal of Inflammation | / 7卷
关键词：
Brain Death; Cold Storage; Cold Ischemia; Acute Rejection Episode; Transplant Setting;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Inflammatory reactions in the graft have a pivotal influence on acute as well as long-term graft function. The main reasons for an inflammatory reaction of the graft tissue are rejection episodes, infections as well as ischemia/reperfusion (I/R) injury. The latter is of particular interest as it affects every solid organ during the process of transplantation. I/R injury impairs acute as well as long-term graft function and is associated with an increased number of acute rejection episodes that again affect long-term graft outcome.
引用
收藏
相关论文
共 538 条
[1]  
Gueler F(2004)Long-term effects of acute ischemia and reperfusion injury Kidney Int 66 523-527
[2]  
Gwinner W(2008)Ischemia/reperfusion injury in kidney transplantation: mechanisms and prevention Transplant Proc 40 3279-3288
[3]  
Schwarz A(2008)Antioxidant therapy for prevention of inflammation, ischemic reperfusion injuries and allograft rejection Cardiovasc Hematol Agents Med Chem 6 20-43
[4]  
Haller H(1998)Hydrogen peroxide induces tumor necrosis factor alpha-mediated cardiac injury by a P38 mitogen-activated protein kinase-dependent mechanism Surgery 124 291-296
[5]  
Kosieradzki M(2002)The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta Mol Cell 10 417-426
[6]  
Rowinski W(2003)Toll-like receptor signalling pathways as key targets for mediating the anti-inflammatory and immunosuppressive effects of glucocorticoids J Endocrinol 179 139-144
[7]  
Ma A(2009)Mechanisms of action, physiological effects, and complications of hypothermia Crit Care Med 37 S186-202
[8]  
Qi S(2008)Roles of chemokines in renal ischemia/reperfusion injury Front Biosci 13 4021-4028
[9]  
Chen H(2009)Systemic inflammation in the brain-dead organ donor Acta Anaesthesiol Scand 53 425-435
[10]  
Meldrum DR(2009)Detrimental consequences of brain injury on peripheral cells Brain Behav Immun 23 877-884
12345678910