The Nox Family of NADPH Oxidases: Friend or Foe of the Vascular System?

被引：0
作者：
Ina Takac
Katrin Schröder
Ralf P. Brandes
机构：
[1] Fachbereich Medizin der Goethe-Universität,Institut für Kardiovaskuläre Physiologie
来源：
Current Hypertension Reports | 2012年 / 14卷
关键词：
NADPH oxidase; Reactive oxygen species; Endothelial dysfunction; Vascular tone; Hypertension; Arteriosclerosis; Angiogenesis; Endothelium; Nitric oxide; Nox proteins;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
NADPH (nicotinamide adenine dinucleotide phosphate) oxidases are important sources of reactive oxygen species (ROS). In the vascular system, ROS can have both beneficial and detrimental effects. Under physiologic conditions, ROS are involved in signaling pathways that regulate vascular tone as well as cellular processes like proliferation, migration and differentiation. However, high doses of ROS, which are produced after induction or activation of NADPH oxidases in response to cardiovascular risk factors and inflammation, contribute to the development of endothelial dysfunction and vascular disease. In vascular cells, the NADPH oxidase isoforms Nox1, Nox2, Nox4, and Nox5 are expressed, which differ in their activity, response to stimuli, and the type of ROS released. This review focuses on the specific role of different NADPH oxidase isoforms in vascular physiology and their potential contributions to vascular diseases.
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页码：70 / 78
页数：8
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