The cell biology of neuronal navigation

被引：0
作者：
Hong-jun Song
Mu-ming Poo
机构：
[1] Molecular Neurobiology Laboratory,Department of Molecular and Cell Biology
[2] Salk Institute for Biological Studies,undefined
[3] University of California,undefined
来源：
Nature Cell Biology | 2001年 / 3卷
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摘要：
Morphogenesis of the nervous system requires the directed migration of postmitotic neurons to designated locations in the nervous system and the guidance of axon growth cones to their synaptic targets. Evidence suggests that both forms of navigation depend on common guidance molecules, surface receptors and signal transduction pathways that link receptor activation to cytoskeletal reorganization. Future challenges remain not only in identifying all the components of the signalling pathways, but also in understanding how these pathways achieve signal amplification and adaptation—two essential cellular processes for neuronal navigation.
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页码：E81 / E88
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