BRCA1 and BRCA1 Genes and Inherited Breast and/or Ovarian Cancer: Benefits of Genetic Testing

被引：7

作者：

Somasundaram K. ^{[1
]}

机构：

[1] Microbiology and Cell biology, Indian Institute of Science

来源：

Indian Journal of Surgical Oncology | 2010年 / 1卷 / 3期

关键词：

BRCA1; BRCA2; Familial breast and/or ovarian cancer; Inherited breast cancer;

D O I：

10.1007/s13193-011-0049-7

中图分类号：

学科分类号：

摘要：

The breast cancer associated genes BRCA1 and BRCA2 were discovered in 1994 and 1995 respectively. Since then in addition to our understanding how these proteins function in particular reference to DNA repair, enormous amount of knowledge has been gained regarding genetic epidemiology of inherited breast and ovarian cancer, mutation prevalence among different ethnic groups, presence of founder mutations, varying penetrance, genetic testing and potential management options of mutation carriers. This review will focus on the status of understanding of the role of BRCA1 and BRAC2 mutations among Indian women, structure and biology of these two genes, different methods used for mutation detection and different management options available for BRCA1 and BRCA2 mutation carriers. © 2011 Indian Association of Surgical Oncology.

引用

页码：245 / 249

页数：4

共 26 条

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