Direct proteome profiling of the blood serum in cosmonauts after long-term space missions

被引：3
|
作者：
Pakharukova N.A. [1 ,2 ]
Pastushkova L.K. [1 ,2 ]
Samarin G.I. [1 ]
Pochuev V.I. [3 ]
Morukov B.V. [1 ]
Larina I.M. [1 ,2 ]
机构：
[1] Institute of Biomedical Problems, Moscow
[2] Russian-French Associated Laboratory CaDyWEC, Angers
[3] Gagarin Research and Test Cosmonaut Training Center, Zvezdnyi Gorodok, Moscow oblast
来源：
Human Physiology | 2014年 / 40卷 / 7期
基金：
俄罗斯基础研究基金会;
关键词：
Fibrinogen; Blood Serum; Space Mission; Proteome Profile; Proteolytic System;
D O I：
10.1134/S0362119714070196
中图分类号：
学科分类号：
摘要：
The aim of the present study was to examine the changes in the proteome profile of the blood serum in seven Russian cosmonauts after long-term space missions aboard International Space Station. Blood was sampled 45–60 days prior to and 1 and 7 days after the end of the mission. One day after the end of vmission, we found a decrease in the peaks of β2-microglobulin and apolipoprotein CI. Additionally, we revealed shifts in functioning of the proteolytic systems of the blood, which were reflected in the changes in peak areas for specific proteins, such as fibrinogen, complement C3, high-molecular-weight kininogen, inhibitor of inter-α-trypsin, and clusterin. © 2014, Pleiades Publishing, Inc.
引用
收藏
页码：713 / 717
页数：4
相关论文
共 50 条
  • [1] Characteristics of blood plasma proteome changes associated with the hemorrhagic purpura of cosmonauts on the first day after long-term space missions
    Pastushkova, L. Kh
    Goncharov, I. N.
    Koloteva, M., I
    Goncharova, A. G.
    Kashirina, D. N.
    Nosovsky, A. M.
    Glebova, T. M.
    Kononikhin, A. S.
    Borchers, C. H.
    Nikolaev, E. N.
    Larina, I. M.
    LIFE SCIENCES IN SPACE RESEARCH, 2022, 33 : 7 - 12
  • [2] Immunological, hormonal and hemostasis parameters in cosmonauts' blood after long-term orbital missions
    Kuzichkin, D. S.
    Nichiporuk, I. A.
    Rykova, M. P.
    Zhuravleva, O. A.
    Markin, A. A.
    Zhuravleva, T. V.
    Sadova, A. A.
    Chistokhodova, S. A.
    Kutko, O. V.
    Ponomarev, S. A.
    ACTA ASTRONAUTICA, 2023, 211 : 650 - 654
  • [3] Osteoclast-activating system in cosmonauts after long-term international space station missions
    Morukov I.B.
    Rykova M.P.
    Antropova E.N.
    Berendeeva T.A.
    Ponomarev S.A.
    Morukov B.V.
    Human Physiology, 2016, 42 (7) : 719 - 723
  • [4] Toll-Like Receptors in Peripheral Blood Cells of Cosmonauts after Long-term Missions on Board the International Space Station
    Berendeeva T.A.
    Ponomarev S.A.
    Antropova E.N.
    Rykova M.P.
    Human Physiology, 2017, 43 (7) : 802 - 807
  • [5] Bone Mineral Density and Molecular Genetic Markers of Bone Remodeling in Blood of Cosmonauts after Long-term Missions on Board the International Space Station
    Novikov V.E.
    Rykova M.P.
    Antropova E.N.
    Berendeeva T.A.
    Kalinin S.A.
    Vassilieva G.Y.
    Ponomarev S.A.
    Human Physiology, 2017, 43 (6) : 686 - 692
  • [6] The dynamics of blood biochemical parameters in cosmonauts during long-term space flights
    Markin, A
    Strogonova, L
    Balashov, O
    Polyakov, V
    Tigner, T
    ACTA ASTRONAUTICA, 1998, 42 (1-8) : 247 - 253
  • [7] Cytogenetic studies of blood lymphocytes from cosmonauts after long-term space flights on MIR station
    Fedorenko, B
    Druzhinin, S
    Yudaeva, L
    Petrov, V
    Akatov, Y
    Snigiryova, G
    Novitskaya, N
    Shevchenko, V
    Rubanovich, A
    SPACE LIFE SCIENCES: LIFE IN THE SOLAR SYSTEM: PREBIOTIC CHEMISTRY, CHIRALITY AND SPACE BIOLOGY, 2001, 27 (02): : 355 - 359
  • [8] Cluster analysis in the fitness evaluation of cosmonauts during long-term missions on board the International Space Station
    Egorov A.D.
    Stepantsov V.I.
    Nosovskii A.M.
    Shipov A.A.
    Human Physiology, 2011, 37 (7) : 922 - 923
  • [9] DOUBTS OVER LONG-TERM SPACE-FLIGHT AFTER COSMONAUTS DEATH
    RICH, V
    NATURE, 1988, 334 (6183) : 557 - 557
  • [10] Proteome Profiling of the Exhaled Breath Condensate after Long-Term Spaceflights
    Kononikhin, Alexey S.
    Brzhozovskiy, Alexander G.
    Ryabokon, Anna M.
    Fedorchenko, Kristina
    Zhakharova, Natalia V.
    Spasskii, Alexander I.
    Popov, Igor A.
    Ilyin, Vyacheslav K.
    Solovyova, Zoya O.
    Pastushkova, Lyudmila Kh.
    Polyakov, Alexey V.
    Varfolomeev, Sergey D.
    Larina, Irina M.
    Nikolaev, Evgeny N.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (18)
12345