Functioning of the Antioxidant Defense System in Rotenone-Induced Parkinson’s Disease

被引：0
作者：
E. D. Kryl’skii
G. A. Razuvaev
T. N. Potapova
A. I. Akinina
L. E. Nihaev
机构：
[1] Voronezh State University,Department of Medical Biochemistry and Microbiology
来源：
Bulletin of Experimental Biology and Medicine | 2021年 / 171卷
关键词：
Parkinson’s disease; oxidative stress; antioxidant system; rotenone;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A comprehensive study of the functioning of antioxidant system in rats with rotenone-induced parkinsonism was conducted. The development of pathology led to inhibition of the majority of the studied antioxidant enzymes in the brain and blood serum of animals, which can be associated with decompensation of oxidative stress under conditions of prolonged mitochondrial dysfunction. These changes apparently make an important contribution into neuronal degeneration in the cerebral cortex and striatum and motor disorders in experimental animals.
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页码：716 / 721
页数：5
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