Endothelin-like immunoreactivity in aqueous humor of patients with primary open-angle glaucoma and cataract

被引：0

作者：

Walter Noske

Johannes Hensen

Michael Wiederholt

机构：

[1] Benjamin Franklin University Hospital,Department of Ophthalmology

[2] Free University of Berlin,Department of Internal Medicine

[3] Friedrich-Alexander University Erlangen-Nürnberg,Department of Clinical Physiology

[4] Benjamin Franklin University Hospital,undefined

[5] Free University of Berlin,undefined

来源：

Graefe's Archive for Clinical and Experimental Ophthalmology | 1997年 / 235卷

关键词：

Public Health; Glaucoma; Experimental Evidence; Cataract; Intraocular Pressure;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

• Background: Experimental evidence suggests a role of endothelin-1 (ET) in the regulation of intraocular pressure (IOP). • Method: Therefore, inpatients undergoing cataract surgery, ET-like immunoreactivity (STIR) was measured by radioimmunoassay in pooled samples of aqueous humor of eyes with primary open-angle glaucoma (POAG) and normotensive eyes with cataract only. • Results: ETIR was significantly (P < 0.05) higher in patients with cataract and POAG (20.5 ± 1.8 pg/ml,n = 12; preoperative IOP 21.4 ± I.1 mmHg,n = 33) than in patients with cataract only (15.8 ± 1.6 pg/m1,n = 15; preoperative IOP 16.0 ± 0.6 mmHg,n = 77). • Conclusion: This finding may indicate a role of ET in POAG or ocular antihypertensive treatment, and its relevance should be further investigated.

引用

页码：551 / 552

页数：1

共 22 条

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[6]

Hammer J(undefined)undefined undefined undefined undefined-undefined

[7]

Wenk M(undefined)undefined undefined undefined undefined-undefined

[8]

Lüscher T(undefined)undefined undefined undefined undefined-undefined

[9]

Lepple-Wienhues A(undefined)undefined undefined undefined undefined-undefined

[10]

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