Colonization of xenograft tumors by oncolytic vaccinia virus (VACV) results in enhanced tumor killing due to the involvement of myeloid cells

被引:0
作者
Mehmet Okyay Kilinc
Klaas Ehrig
Maysam Pessian
Boris R. Minev
Aladar A. Szalay
机构
[1] University of Würzburg,Department of Biochemistry, Biocenter
[2] Genelux Corporation,San Diego Science Center
[3] University of California,Department of Radiation Medicine and Applied Sciences, Rebecca & John Moores Comprehensive Cancer Center
来源
Journal of Translational Medicine | / 14卷
关键词
MDSCs; VACV; iNOS; Oncolytic virus therapy; NO; Innate immune system; Antitumor immune response; Antiviral immunity;
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[1]  
Wein LM(2003)Validation and analysis of a mathematical model of a replication-competent oncolytic virus for cancer treatment: implications for virus design and delivery Cancer Res 63 1317-1324
[2]  
Wu JT(2010)Oncolytic vaccinia virus: a theranostic agent for cancer Future Virol 5 763-784
[3]  
Kirn DH(2012)Preferential colonization of metastases by oncolytic vaccinia virus strain GLV-1h68 in a human PC-3 prostate cancer model in nude mice PLoS ONE 7 e45942-2392
[4]  
Chen NG(2013)Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity J Gen Virol 94 2367-499
[5]  
Szalay AA(2014)A novel vaccinia virus with dual oncolytic and anti-angiogenic therapeutic effects against triple-negative breast cancer Breast Cancer Res Treat 148 489-394
[6]  
Donat U(2006)Prostate tumor cells infected with a recombinant influenza virus expressing a truncated NS1 protein activate cytolytic CD8+ cells to recognize noninfected tumor cells J Virol 80 383-59
[7]  
Smith GL(2012)Neoplastic “Black Ops”: cancer’s subversive tactics in overcoming host defenses Semin Cancer Biol 22 50-174
[8]  
Gholami S(2009)Myeloid-derived suppressor cells as regulators of the immune system Nat Rev Immunol 9 162-5802
[9]  
Efferson CL(2008)Subsets of myeloid-derived suppressor cells in tumor-bearing mice J Immunol 181 5791-4244
[10]  
Biragyn A(2008)Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity Blood 111 4233-179