A two-amino-acid substitution in the transcription factor RORγt disrupts its function in TH17 differentiation but not in thymocyte development

被引：0
作者：
Zhiheng He
Jian Ma
Ruiqing Wang
Jing Zhang
Zhaofeng Huang
Fei Wang
Subha Sen
Ellen V Rothenberg
Zuoming Sun
机构：
[1] Beckman Research Institute of City of Hope,Division of Molecular Immunology
[2] Irell & Manella Graduate School of Biological Sciences,Division of Biology & Biological Engineering
[3] City of Hope,undefined
[4] Zhongshan School of Medicine,undefined
[5] Sun Yat-sen University,undefined
[6] California Institute of Technology,undefined
来源：
Nature Immunology | 2017年 / 18卷
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摘要：
Targeting the transcription factor RORγt in autoimmunity could disrupt thymocyte development and lead to thymic lymphoma. Sun and colleagues identify a two-amino-acid substitution in RORγt that ‘preferentially’ disrupts TH17 differentiation, not thymocyte development.
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页码：1128 / 1138
页数：10
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