A two-amino-acid substitution in the transcription factor RORγt disrupts its function in TH17 differentiation but not in thymocyte development

被引：0

作者：

Zhiheng He

Jian Ma

Ruiqing Wang

Jing Zhang

Zhaofeng Huang

Fei Wang

Subha Sen

Ellen V Rothenberg

Zuoming Sun

机构：

[1] Beckman Research Institute of City of Hope,Division of Molecular Immunology

[2] Irell & Manella Graduate School of Biological Sciences,Division of Biology & Biological Engineering

[3] City of Hope,undefined

[4] Zhongshan School of Medicine,undefined

[5] Sun Yat-sen University,undefined

[6] California Institute of Technology,undefined

来源：

Nature Immunology | 2017年 / 18卷

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暂无

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学科分类号：

摘要：

Targeting the transcription factor RORγt in autoimmunity could disrupt thymocyte development and lead to thymic lymphoma. Sun and colleagues identify a two-amino-acid substitution in RORγt that ‘preferentially’ disrupts TH17 differentiation, not thymocyte development.

引用

页码：1128 / 1138

页数：10

共 29 条

[1] A two-amino-acid substitution in the transcription factor RORγgt disrupts its function in TH17 differentiation but not in thymocyte development
He, Zhiheng
Ma, Jian
Wang, Ruiqing
Zhang, Jing
Huang, Zhaofeng
Wang, Fei
Sen, Subha
Rothenberg, Ellen V.
Sun, Zuoming
NATURE IMMUNOLOGY, 2017, 18 (10) : 1128 - +
[2] Sumoylation of RORγt regulates TH17 differentiation and thymocyte development
He, Zhiheng
Zhang, Jing
Huang, Zhaofeng
Du, Qian
Li, Ning
Zhang, Qiang
Chen, Yuan
Sun, Zuoming
NATURE COMMUNICATIONS, 2018, 9
[3] Sumoylation of RORγt regulates TH17 differentiation and thymocyte development
Zhiheng He
Jing Zhang
Zhaofeng Huang
Qian Du
Ning Li
Qiang Zhang
Yuan Chen
Zuoming Sun
Nature Communications, 9
[4] SRC3 Is a Cofactor for RORγt in Th17 Differentiation but Not Thymocyte Development
He, Zhiheng
Zhang, Jing
Du, Qian
Xu, Jianming
Gwack, Yousang
Sun, Zuoming
JOURNAL OF IMMUNOLOGY, 2019, 202 (03): : 760 - 769
[5] Separation of RORgammat function in Thymocyte development and Th17 differentiation
Sun, Zuoming
He, Zhiheng
Ma, Jian
JOURNAL OF IMMUNOLOGY, 2018, 200 (01):
[6] Cutting Edge: The Transcription Factor Kruppel-Like Factor 4 Regulates the Differentiation of Th17 Cells Independently of RORγt
Lebson, Lori
Gocke, Anne
Rosenzweig, Jason
Alder, Jonathan
Civin, Curt
Calabresi, Peter A.
Whartenby, Katharine A.
JOURNAL OF IMMUNOLOGY, 2010, 185 (12): : 7161 - 7164
[7] AIM2 promotes TH17 cells differentiation by regulating RORγt transcription activity
Leite, Jefferson Antonio
Menezes, Luisa
Martins, Eloisa
Rodrigues, Tamara Silva
Tavares, Lucas
Ebering, Anna
Schelmbauer, Carsten
Cebinelli, Guilherme C. Martelossi
Zinina, Valeriya
Golden, Artemiy
Soshnikova, Natalia
Zamboni, Dario S.
Cunha, Fernando Q.
Huber, Magdalena
Silva, Joao Santana
Waisman, Ari
Carlos, Daniela
Camara, Niels Olsen Saraiva
ISCIENCE, 2023, 26 (11)
[8] Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity
Jun R. Huh
Monica W. L. Leung
Pengxiang Huang
Daniel A. Ryan
Michael R. Krout
Raghu R. V. Malapaka
Jonathan Chow
Nicolas Manel
Maria Ciofani
Sangwon V. Kim
Adolfo Cuesta
Fabio R. Santori
Juan J. Lafaille
H. Eric Xu
David Y. Gin
Fraydoon Rastinejad
Dan R. Littman
Nature, 2011, 472 : 486 - 490
[9] Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity
Huh, Jun R.
Leung, Monica W. L.
Huang, Pengxiang
Ryan, Daniel A.
Krout, Michael R.
Malapaka, Raghu R. V.
Chow, Jonathan
Manel, Nicolas
Ciofani, Maria
Kim, Sangwon V.
Cuesta, Adolfo
Santori, Fabio R.
Lafaille, Juan J.
Xu, H. Eric
Gin, David Y.
Rastinejad, Fraydoon
Littman, Dan R.
NATURE, 2011, 472 (7344) : 486 - 490
[10] Separating RORgammat function in Th17 differentiation and T cell development
Sun, Zuoming
Ma, Jian
He, Zhiheng
JOURNAL OF IMMUNOLOGY, 2016, 196

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