Double-blind crossover study to assess potential differences in cytochrome P450 3A4 activity in healthy subjects receiving ondansetron plus dexamethasone, with and without aprepitant

被引:0
作者
S. Aubrey Stoch
Cynthia Gargano
Jack Valentine
Matthew P. Braun
M. Gail Murphy
Margaret Fedgchin
Anup Majumdar
Edward Pequignot
Keith M. Gottesdiener
Kevin J. Petty
Deborah Panebianco
Dennis Dean
Walter K. Kraft
Howard E. Greenberg
机构
[1] Merck Research Laboratories,Department of Pharmacology and Experimental Therapeutics
[2] Merck Research Laboratories,undefined
[3] Merck Research Laboratories,undefined
[4] Thomas Jefferson University,undefined
[5] Clinilabs Inc.,undefined
来源
Cancer Chemotherapy and Pharmacology | 2011年 / 67卷
关键词
Aprepitant; Midazolam; Ondansetron; CYP3A4; Pharmacokinetics; Nausea/vomiting;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:1313 / 1321
页数:8
相关论文
共 162 条
[1]  
Kris MG(2006)American Society of Clinical Oncology guideline for antiemetics in oncology: update 2006 J Clin Oncol 24 2932-2947
[2]  
Hesketh PJ(2004)Evaluation of potential inductive effects of aprepitant on cytochrome P450 3A4 and 2C9 activity J Clin Pharmacol 44 215-223
[3]  
Somerfield MR(2003)Effects of aprepitant on cytochrome P450 3A4 activity using midazolam as a probe Clin Pharmacol Ther 74 150-156
[4]  
Feyer P(2003)Effects of aprepitant on the pharmacokinetics of ondansetron and granisetron in healthy subjects Clin Ther 25 1407-1419
[5]  
Clark-Snow R(2006)Lack of effect of aprepitant on hydrodolasetron pharmacokinetics in CYP2D6 extensive and poor metabolizers J Clin Pharmacol 46 792-801
[6]  
Koeller JM(2005)Pharmacokinetics of palonosetron in combination with aprepitant in healthy volunteers Curr Med Res Opin 21 595-601
[7]  
Morrow GR(1989)Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450: studies in rats and patients J Clin Invest 3 688-697
[8]  
Chinnery LW(2000)In vivo and in vitro induction of human cytochrome P4503A4 by dexamethasone Clin Pharmacol Ther 68 356-366
[9]  
Chesney MJ(2001)Use of the erythromycin breath test for in vivo assessments of cytochrome P4503A activity and dosage individualization Clin Pharmacol Ther 70 305-310
[10]  
Gralla RJ(1999)Failure of erythromycin breath test to correlate with midazolam clearance as a probe of cytochrome P4503A Clin Pharmacol Ther 66 224-231