Emerging issues in the neuropsychology of HIV infection

被引：30

作者：

Foley J. ^{[1
]}

Ettenhofer M. ^{[1
]}

Wright M. ^{[1
]}

Hinkin C.H. ^{[1
]}

机构：

[1] David Geffen School of Medicine, UCLA, Los Angeles, CA 90024

来源：

Current HIV/AIDS Reports | 2008年 / 5卷 / 4期

关键词：

Dementia; Diffusion Tensor Imaging; Medication Adherence; Neurocognitive Impairment; Minor Cognitive Motor Disorder;

D O I：

10.1007/s11904-008-0029-x

中图分类号：

学科分类号：

摘要：

Neurocognitive compromise, a common sequela of HIV infection, ranges in severity from minor motor and information-processing speed decrements to severely incapacitating symptoms that affect functional independence. However, with the emergence of highly active antiretroviral therapy (HAART), neurocognitive phenotypes have become highly heterogeneous and increasingly fail to resemble pre-HAART presentations. This article provides an overview of our current knowledge of HIV-associated neuropsychological abnormalities, with an emphasis on the most recent attempts to classify cognitive impairment within Western and developing societies, the emergence of diverse cognitive presentations in the post-HAART era, factors that moderate the development or impact of HIV-related neurocognitive and functional deficits, and the neurophysiologic consequences of infection. Copyright © 2008 by Current Medicine Group LLC.

引用

页码：204 / 211

页数：7

共 45 条

[11]

Hinkin C.H., van Gorp W.G., Mandelkern M.A., Et al., Cerebral metabolic change in patients with AIDS: Report of a six-month follow-up using positron-emission tomography, J Neuropsychiatry Clin Neurosci, 7, pp. 180-187, (1995)

[12]

Marcotte T.D., Deutsch R., McCutchan J.A., Et al., Prediction of incident neurocognitive impairment by plasma RNA and CD4 levels early after HIV seroconversion, Arch Neurol, 60, pp. 1406-1412, (2003)

[13]

Hardy D.J., Hinkin C.H., Levine A.J., Et al., Risky decision making assessed with the gambling task in adults with HIV, Neuropsychology, 20, pp. 355-360, (2006)

[14]

Clinical confirmation of the American Academy of Neurology algorithm for HIV-1-associated cognitive/motor disorder, Neurology, 47, pp. 1247-1253, (1996)

[15]

Robertson K.R., Nakasujja N., Wong M., Et al., Pattern of neuropsychological performance among HIV positive patients in Uganda, BMC Neurology, 7, pp. 8-15, (2007)

[16]

Vasan A., Renjifo B., Hertzmark E., Et al., Different rates of disease progression on HIV type 1 infection in Tanzania based on infecting subtype, Clin Infect Dis, 42, pp. 843-852, (2006)

[17]

Wong M., Robertson K., Nakasujja N., Et al., Frequency of and risk factors for HIV dementia in an HIV clinic in sub-Saharan Africa, Neurology, 68, pp. 350-355, (2007)

[18]

Sacktor N., The epidemiology of human immunodeficiency virus-associated neurological disease in the era of highly active antiretroviral therapy, J Neurovirol, 8, SUPPL. 2, pp. 115-121, (2002)

[19]

McArthur J.C., HIV dementia, J Neuroimmunol, 157, pp. 3-10, (2004)

[20]

HIV/AIDS Surveillance Report, 2005, (2007)

← 1 2 3 4 5 →