Genetic correlation between multiple myeloma and chronic lymphocytic leukaemia provides evidence for shared aetiology

被引：0

作者：

Molly Went

Amit Sud

Helen Speedy

Nicola J. Sunter

Asta Försti

Philip J. Law

David C. Johnson

Fabio Mirabella

Amy Holroyd

Ni Li

Giulia Orlando

Niels Weinhold

Mark van Duin

Bowang Chen

Jonathan S. Mitchell

Larry Mansouri

Gunnar Juliusson

Karin E Smedby

Sandrine Jayne

Aneela Majid

Claire Dearden

David J. Allsup

James R. Bailey

Guy Pratt

Chris Pepper

Chris Fegan

Richard Rosenquist

Rowan Kuiper

Owen W. Stephens

Uta Bertsch

Peter Broderick

Hermann Einsele

Walter M. Gregory

Jens Hillengass

Per Hoffmann

Graham H. Jackson

Karl-Heinz Jöckel

Jolanta Nickel

Markus M. Nöthen

Miguel Inacio da Silva Filho

Hauke Thomsen

Brian A. Walker

Annemiek Broyl

Faith E. Davies

Markus Hansson

Hartmut Goldschmidt

Martin J. S. Dyer

Martin Kaiser

Pieter Sonneveld

Gareth J. Morgan

机构：

[1] The Institute of Cancer Research,Division of Genetics and Epidemiology

[2] Newcastle University,Northern Institute for Cancer Research

[3] German Cancer Research Center,Center for Primary Health Care Research

[4] Lund University,Division of Molecular Pathology

[5] The Institute of Cancer Research,Myeloma Institute for Research and Therapy

[6] University of Arkansas for Medical Sciences,Department of Internal Medicine V

[7] University of Heidelberg,Department of Hematology

[8] Erasmus MC Cancer Institute,Department of Immunology, Genetics and Pathology, Science for Life Laboratory

[9] Uppsala University,Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Hematology and Transplantation

[10] Lund University,Unit of Clinical Epidemiology, Department of Medicine

[11] Karolinska Institutet,Ernest and Helen Scott Haematological Research Institute

[12] Leicester University,Department of Haematology

[13] Hull Royal Infirmary,Department of Haematology

[14] Hull York Medical School and University of Hull,Department of Haematology, School of Medicine

[15] Birmingham Heartlands Hospital,Clinical Trials Research Unit

[16] Cardiff University,Institute of Human Genetics

[17] Cardiff and Vale National Health Service Trust,Division of Medical Genetics, Department of Biomedicine

[18] Heath Park,Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen

[19] National Centre of Tumor Diseases,Institute of Human Genetics

[20] University Clinic of Würzburg,Department of Genomics, Life and Brain Center

[21] University of Leeds,Hematology and Transfusion Medicine, Department of Laboratory Medicine, BMC B13

[22] University of Bonn,Broad Institute

[23] University of Basel,undefined

[24] Royal Victoria Infirmary,undefined

[25] University of Duisburg–Essen,undefined

[26] University of Bonn,undefined

[27] University of Bonn,undefined

[28] SE-221 84 Lund University,undefined

[29] 7 Cambridge Center,undefined

来源：

Blood Cancer Journal | / 9卷

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摘要：

The clustering of different types of B-cell malignancies in families raises the possibility of shared aetiology. To examine this, we performed cross-trait linkage disequilibrium (LD)-score regression of multiple myeloma (MM) and chronic lymphocytic leukaemia (CLL) genome-wide association study (GWAS) data sets, totalling 11,734 cases and 29,468 controls. A significant genetic correlation between these two B-cell malignancies was shown (Rg = 0.4, P = 0.0046). Furthermore, four of the 45 known CLL risk loci were shown to associate with MM risk and five of the 23 known MM risk loci associate with CLL risk. By integrating eQTL, Hi-C and ChIP-seq data, we show that these pleiotropic risk loci are enriched for B-cell regulatory elements and implicate B-cell developmental genes. These data identify shared biological pathways influencing the development of CLL and, MM and further our understanding of the aetiological basis of these B-cell malignancies.

引用

共 81 条

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