Recent Advances in Structure-Based Virtual Screening of G-Protein Coupled Receptors

被引：0
|
作者：
Subramaniam Ananthan
Wei Zhang
Judith Varady Hobrath
机构：
[1] Southern Research Institute,Drug Discovery Division
来源：
The AAPS Journal | 2009年 / 11卷
关键词：
GPCRs; homology modeling; virtual screening;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In addition to the rhodopsin crystal structure, high-resolution crystal structures of ligand-mediated G-protein-coupled receptors (GPCRs) have recently become available, and these have become attractive templates for developing homology models of several GPCRs of therapeutic interest. These crystal structures and the homology models derived from them have provided significant insights into ligand–receptor interactions. Moreover, several studies have demonstrated that the structural models are indeed suitable for virtual screening of compound databases to identify new ligands for various GPCRs. Recent examples of such virtual screening against GPCRs are discussed in this review.
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页码：178 / 185
页数：7
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