The role of regulatory t lymphocytes in asthma pathogenesis

被引：0

作者：

Douglas S. Robinson

机构：

[1] National Heart and Lung Institute,Leukocyte Biology Section, Biomedical Sciences Division and Allergy and Clinical Immunology

[2] Faculty of Medicine,undefined

[3] Imperial College London,undefined

来源：

Current Allergy and Asthma Reports | 2005年 / 5卷

关键词：

Asthma; Allergic Disease; Fluticasone Propionate; Allergy Clin Immunol; House Dust Mite;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Several subtypes of regulatory or suppressive T cells have been described that can prevent activation of effector T cells in vitro and in vivo in animal models. Recent evidence suggests a deficit in suppressive activity of both CD4+CD25+ regulatory T cells, and interleukin (IL)•10 producing regulatory T cells may play a role in development of allergic sensitization. If therapies can be devised to redress the balance between regulatory and effector T cells, there may be hope for the control and prevention of asthma.

引用

页码：136 / 141

页数：5

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