Biological Composites Based on Fluoropolymers with Hydroxyapatite for Intramedullary Implants

被引：8

作者：

Aronov A.M. ^{[1
]}

Bol'basov E.N. ^{[2
]}

Guzeev V.V. ^{[2
]}

Dvornichenko M.V. ^{[2
]}

Tverdokhlebov S.I. ^{[3
]}

Khlusov I.A. ^{[2
]}

机构：

[1] Siberian Scientific-Research and Test Center for Biomedical Engineering, Novosibirsk

[2] Ilizarov Russian Scientific Center of Recovery Traumatology and Orthopedics, Tomsk, Tomsk Branch

[3] Tomsk Polytechnic University, Tomsk

来源：

Biomedical Engineering | 2010年 / 44卷 / 3期

关键词：

Calcium Phosphate; Total Porosity; Vinylidene Fluo Ride; Pore Area; Biocomposite Film;

D O I：

10.1007/s10527-010-9166-9

中图分类号：

学科分类号：

摘要：

A new type of composite materials for application as coatings for intramedullary implants in the field of orthopedics and traumatology is described. The method is based on the ability of fluoropolymers to act as a biologically inert binding agent and ability of fine-dispersed hydroxyapatite powders to act as a biologically active filling agent providing osteoinduction and osteoconduction processes. The results of the study of adhesion, elastic, and morphometric parameters of the composite are presented; chemical composition is reported. The toxicological properties, local irritant action, and hemolytic activity of the composites were determined according to GOST R ISO 10993. The in vivo tests demonstrated that the composites do not cause any negative tissue reactions and stimulate osteogenesis processes in ectopic bone formation test. © 2010 Springer Science+Business Media, Inc.

引用

页码：108 / 113

页数：5

共 13 条

[1]

Burlakov E.V., Alatov D.V., Popkov D.A., Shutov R.B., Med. Tekh., 3, pp. 26-28, (2008)

[2]

Shutov R.B., Surgical Extension of Congenital Shortened Shin Using and Automatic Distraction and Intramedullary Armoring with Hydroxyapatite-Coated Spokes: Candidate Dissertation, (2009)

[3]

Sharkeev Y.P., Kolobov A.V., Khlusov I.A., Karlov A.V., Legostaeva E.V., Shashkina G.A., Fiz. Mezomekh., 8, pp. 83-86, (2004)

[4]

Karlov A.V., Shakhov V.P., External Fixation Systems and Regulatory Mechanisms of Optimal Biomechanics, (2001)

[5]

Guzeev V.V., Vereshchagin V.I., Guzeev V.V., Steklo Keram, 6, (2000)

[6]

Aronov A.M., Pichugin V.F., Eshenko E.V., Ryabtseva M.A., Surmenev R.A., Tverdokhlebov S.I., Shesterikov E.V., Med. Tekh., 3, pp. 18-22, (2008)

[7]

Hench L., Jones J., Biomaterials, Artificial Organs and Tissue Engineering, (2007)

[8]

Barinov S.M., Komlev V.S., Calcium Phosphate-Based Bioceramics, (2005)

[9]

Kataeva V.M., Popova V.A., Sazhina B.I., Handbook on Plastics, 1, (1975)

[10]

Grafskaya N.D., Comparative Assessment of Network Polymers as Alloimplants of Abdominal Mesh in Patients with Hernia: Candidate Dissertation, (1967)

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