Development of anti-TNF therapy for rheumatoid arthritis

被引：0
作者：
Marc Feldmann
机构：
[1] Kennedy Institute,the Rheumatology Division
[2] Faculty of Medicine,undefined
[3] Imperial College School of Medicine,undefined
[4] ARC Building,undefined
来源：
Nature Reviews Immunology | 2002年 / 2卷
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摘要：
The aetiology of systemic, autoimmune, chronic inflammatory diseases — such as rheumatoid arthritis — is not known, and their pathogenesis is complex and multifactorial. However, progress in the characterization of intercellular mediators — proteins that are now known as cytokines — has led to the realization that one cytokine, tumour-necrosis factor (TNF; previously known as TNF-α), has an important role in the pathogenesis of rheumatoid arthritis. This discovery heralded a new era of targeted and highly effective therapeutics for rheumatoid arthritis and, subsequently, other chronic inflammatory diseases.
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页码：364 / 371
页数：7
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