Extraocular Muscle Repair and Regeneration

被引：27
作者：
Verma M. [1 ]
Fitzpatrick K.R. [1 ,2 ]
McLoon L.K. [1 ,2 ,3 ]
机构：
[1] Stem Cell Institute, University of Minnesota, Minneapolis, MN
[2] Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Room 374 Lions Research Building, 2001 6th Street SE, Minneapolis, 55455, MN
[3] Department of Neuroscience, University of Minnesota, Minneapolis, MN
来源：
Current Ophthalmology Reports | 2017年 / 5卷 / 3期
基金：
美国国家卫生研究院;
关键词：
Extraocular muscle; Pax7; Pitx2; Satellite cells; Strabismus surgery;
D O I：
10.1007/s40135-017-0141-4
中图分类号：
学科分类号：
摘要：
Purpose of Review: The goal of this review is to summarize the unique regenerative milieu within mature mammalian extraocular muscles (EOMs). This will aid in understanding disease propensity for and sparing of EOMs in skeletal muscle diseases as well as the recalcitrance of the EOM to injury. Recent Findings: The EOMs continually remodel throughout life and contain an extremely enriched number of myogenic precursor cells that differ in number and functional characteristics from those in limb skeletal muscle. The EOMs also contain a large population of Pitx2-positive myogenic precursor cells that provide the EOMs with many of their unusual biological characteristics, such as myofiber remodeling and skeletal muscle disease sparing. This environment provides for rapid and efficient remodeling and regeneration after various types of injury. In addition, the EOMs show a remarkable ability to respond to perturbations of single muscles with coordinated changes in the other EOMs that move in the same plane. Summary: These data will inform ophthalmologists as they work toward developing new treatments for eye movement disorders, new approaches for repair after nerve or direct EOM injury, as well as suggest potential explanations for the unusual disease propensity and disease-sparing characteristics of human EOM. © 2017, Springer Science + Business Media New York.
引用
收藏
页码：207 / 215
页数：8
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