Adaptive changes in the myocardium of patients with ischemic heart disease

被引：2

作者：

Afanas'ev S.A. ^{[1
]}

Pavlyukova E.N. ^{[1
]}

Akhmedov Sh.D. ^{[1
]}

Karpov R.S. ^{[1
]}

机构：

[1] Cardiology Research Institute, Tomsk Research Center, Russian Academy of Medical Sciences, Tomsk

来源：

Human Physiology | 2006年 / 32卷 / 2期

基金：

俄罗斯基础研究基金会;

关键词：

Ischemic Heart Disease; Phosphorylase; Succinate Dehydrogenase; Repeated Exposure; Adaptive Change;

D O I：

10.1134/S0362119706020095

中图分类号：

学科分类号：

摘要：

Changes in the human heart muscle resulting from chronic coronary insufficiency have been analyzed using biopsies taken during surgery from nine patients with ischemic heart disease (IHD) and six patients with the WPW syndrome (without IHD). Histochemical analysis have shown that the atrial myocardium in IHD patients is characterized by an increased density of the microvascular network, increased phosphorylase activity, and decreased succinate dehydrogenase activity. Virtually the same changes have proved to occur in the myocardium of rats adapted to hypoxia by means of repeated exposure in a low-pressure chamber. According to the results of two-dimensional electrophoresis and immunoblotting, acid (but not alkaline) isoforms of inducible HSP70 proteins appear in the myocardium of IHD patients. It is concluded that the myocardium of IHD patients undergoes adaptive changes at the tissue level in response to repeated exposure to ischemia in the course of development of this disease. It is proposed that activation of the synthesis of alkaline HSP70 isoforms in the myocardium of cardiological patients may provide the possibility of improving its resistance to the impact of ischemia and reperfusion (this possibility is not realized under conditions of IHD). © Pleiades Publishing, Inc., 2006.

引用

页码：177 / 181

页数：4

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