Simvastatin Regulates Myocardial Cytokine Expression and Improves Ventricular Remodeling in Rats after Acute Myocardial Infarction

被引：0
作者：
Jinying Zhang
Xiang Cheng
Yu-Hua Liao
Baojun Lu
Yali Yang
Bin Li
Hongxia Ge
Min Wang
Ying Liu
Zhangqiang Guo
Ling Zhang
机构：
[1] Tongji Medical College of Huazhong University of Science and Technology,Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital
[2] Huazhong University of Science and Technology,Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital
来源：
Cardiovascular Drugs and Therapy | 2005年 / 19卷
关键词：
simvastatin; cytokine; ventricular remodeling; myocardial infarction;
D O I：
暂无
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学科分类号：
摘要：
Purpose: Studies have showed that inflammatory cytokines were involved in the process of left ventricular (LV) remodeling after acute myocardial infarction (AMI), anti-inflammation treatment ameliorated LV remodeling and improved cardiac performance. Hydroxymethylglutary coenzyme A reductase inhibition (statins) could affect the expression of inflammatory cytokines. We hypothesized that statins have beneficial effects on early LV remodeling and cardiac performance in rats with AMI by modulating the production of inflammatory cytokines.
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页码：13 / 21
页数：8
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