Inhibition of phosphorylated STAT3 by cucurbitacin I enhances chemoradiosensitivity in medulloblastoma-derived cancer stem cells

被引:0
作者
Charn-Jung Chang
Chih-Hung Chiang
Wen-Shin Song
Shen-Kou Tsai
Lin-Chung Woung
Chin-Hong Chang
Shaw-Yeu Jeng
Ching-Yao Tsai
Chuan-Chih Hsu
Hung-Fu Lee
Chi-Shuan Huang
Ming-Chi Yung
Jorn-Hon Liu
Kai-Hsi Lu
机构
[1] Tri-Service General Hospital and National Defense Medical Center,Department of Pharmacy Practice
[2] Cheng-Hsin General Hospital,Department of Surgery
[3] Cheng-Hsin General Hospital,Department of Medical Research and Education
[4] National Yang-Ming University,School of Medicine
[5] Taipei Veterans General Hospital—Su-Ao/Yuan-Shan Branch,Division of Urology, Department of Surgery
[6] Taipei City Hospital,Department of Ophthalmology
[7] Chi-Mei Medical Center,Department of Surgery
[8] Taiwan Adventist Hospital,Department of Surgery
来源
Child's Nervous System | 2012年 / 28卷
关键词
Medulloblastoma; Cucurbitacin I; Cancer stem cells; CD133; STAT3; Radioresistance;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:363 / 373
页数:10
相关论文
共 50 条
  • [21] Glycomic and Transcriptomic Response of GSC11 Glioblastoma Stem Cells to STAT3 Phosphorylation Inhibition and Serum-Induced Differentiation
    He, Huan
    Nilsson, Carol L.
    Emmett, Mark R.
    Marshall, Alan G.
    Kroes, Roger A.
    Moskal, Joseph R.
    Ji, Yongjie
    Colman, Howard
    Priebe, Waldemar
    Lang, Frederick F.
    Conrad, Charles A.
    JOURNAL OF PROTEOME RESEARCH, 2010, 9 (05) : 2098 - 2108
  • [22] Acquired resistance of pancreatic cancer cells to treatment with gemcitabine and HER-inhibitors is accompanied by increased sensitivity to STAT3 inhibition
    Ioanou, Nikolaos
    Sedon, Alan M.
    Dalgleish, Angus
    Mackintosh, David
    Solca, Flavio
    Modjtahedi, Helmout
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2016, 48 (03) : 908 - 918
  • [23] CD133 receptor mediated delivery of STAT3 inhibitor for simultaneous elimination of cancer cells and cancer stem cells in oral squamous cell carcinoma
    Pindiprolu, Sai Harshini
    Pindiprolu, Sai Kiran S. S.
    MEDICAL HYPOTHESES, 2019, 129
  • [24] JAK/STAT3 and NF-κB Signaling Pathways Regulate Cancer Stem-Cell Properties in Anaplastic Thyroid Cancer Cells
    Shiraiwa, Ken
    Matsuse, Michiko
    Nakazawa, Yuka
    Ogi, Tomoo
    Suzuki, Keiji
    Saenko, Vladimir
    Xu, Shuhang
    Umezawa, Kazuo
    Yamashita, Shunichi
    Tsukamoto, Kazuhiro
    Mitsutake, Norisato
    THYROID, 2019, 29 (05) : 674 - 682
  • [25] IL-32θ inhibits stemness and epithelial-mesenchymal transition of cancer stem cells via the STAT3 pathway in colon cancer
    Bak, Yesol
    Kwon, Taeho
    Bak, In Seon
    Hong, Jintae
    Yu, Dae-Yeul
    Yoon, Do-Young
    ONCOTARGET, 2016, 7 (06) : 7307 - 7317
  • [26] Inhibitory Effects of Tangeretin, a Citrus Peel-Derived Flavonoid, on Breast Cancer Stem Cell Formation through Suppression of Stat3 Signaling
    Ko, Yu-Chan
    Choi, Hack Sun
    Liu, Ren
    Kim, Ji-Hyang
    Kim, Su-Lim
    Yun, Bong-Sik
    Lee, Dong-Sun
    MOLECULES, 2020, 25 (11):
  • [27] STAT3 mediates resistance of CD44(+)CD24(-/low) breast cancer stem cells to tamoxifen in vitro
    Wang, Xiaoyan
    Wang, Guozhu
    Zhao, Yi
    Liu, Xiaoan
    Ding, Qiang
    Shi, Jingping
    Ding, Yin
    Wang, Shui
    JOURNAL OF BIOMEDICAL RESEARCH, 2012, 26 (05): : 325 - 335
  • [28] BMX-ARHGAP fusion protein maintains the tumorigenicity of gastric cancer stem cells by activating the JAK/STAT3 signaling pathway
    Xu, Xiao-Feng
    Gao, Feng
    Wang, Jian-Jiang
    Long, Cong
    Chen, Xing
    Tao, Lan
    Yang, Liu
    Ding, Li
    Ji, Yong
    CANCER CELL INTERNATIONAL, 2019, 19 (1)
  • [29] STAT3 mediates resistance of CD44~+CD24-/low breast cancer stem cells to tamoxifen in vitro
    Xiaoyan Wanga
    bLaboratory of Mesoscopic Chemistry and Department of Polymer Science and Engineering
    The Journal of Biomedical Research, 2012, (05) : 325 - 335
  • [30] BMX-ARHGAP fusion protein maintains the tumorigenicity of gastric cancer stem cells by activating the JAK/STAT3 signaling pathway
    Xiao-Feng Xu
    Feng Gao
    Jian-Jiang Wang
    Cong Long
    Xing Chen
    Lan Tao
    Liu Yang
    Li Ding
    Yong Ji
    Cancer Cell International, 19