Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers

被引：0

作者：

Karoline B Kuchenbaecker

Susan L Neuhausen

Mark Robson

Daniel Barrowdale

Lesley McGuffog

Anna Marie Mulligan

Irene L Andrulis

Amanda B Spurdle

Marjanka K Schmidt

Rita K Schmutzler

Christoph Engel

Barbara Wappenschmidt

Heli Nevanlinna

Mads Thomassen

Melissa Southey

Paolo Radice

Susan J Ramus

Susan M Domchek

Katherine L Nathanson

Andrew Lee

Sue Healey

Robert L Nussbaum

Timothy R Rebbeck

Banu K Arun

Paul James

Beth Y Karlan

Jenny Lester

Ilana Cass

Breast Cancer Family Registry

Mary Beth Terry

Mary B Daly

David E Goldgar

Saundra S Buys

Ramunas Janavicius

Laima Tihomirova

Nadine Tung

Cecilia M Dorfling

Elizabeth J van Rensburg

Linda Steele

Thomas v O Hansen

Bent Ejlertsen

Anne-Marie Gerdes

Finn C Nielsen

Joe Dennis

Julie Cunningham

Steven Hart

Susan Slager

Ana Osorio

Javier Benitez

Mercedes Duran

机构：

[1] University of Cambridge,Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care

[2] Department of Population Sciences,Department of Laboratory Medicine and Pathobiology

[3] Beckman Research Institute of City of Hope,Laboratory Medicine Program

[4] Clinical Genetics Research Laboratory,Departments of Molecular Genetics and Laboratory Medicine and Pathobiology

[5] Memorial Sloan-Kettering Cancer Center,Center for Hereditary Breast and Ovarian Cancer, Medical Faculty

[6] University of Toronto,Center for Integrated Oncology (CIO), Medical Faculty

[7] University Health Network,Center for Molecular Medicine Cologne (CMMC)

[8] Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital,Institute for Medical Informatics

[9] University of Toronto,Center for Molecular Medicine Cologne (CMMC)

[10] Department of Genetics and Computational Biology,Department of Obstetrics and Gynecology

[11] QIMR Berghofer Medical Research Institute,Department of Clinical Genetics

[12] Division of Psychosocial Research and Epidemiology,Department of Pathology, Genetic Epidemiology Laboratory

[13] Netherlands Cancer Institute,Department of Preventive Medicine, Keck School of Medicine

[14] University Hospital Cologne,Department of Medicine, Abramson Cancer Center, Perelman School of Medicine

[15] University Hospital Cologne,Department of Medicine and Institute for Human Genetics

[16] University of Cologne,Abramson Cancer Center and Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine

[17] on behalf of the German Consortium of Hereditary Breast and Ovarian Cancer (GC-HBOC),Sir Peter MacCallum Department of Oncology

[18] Statistics and Epidemiology University of Leipzig,Department of Epidemiology

[19] University of Cologne,Department of Dermatology

[20] University of Helsinki and Helsinki University Central Hospital,Department of Oncological Sciences, Huntsman Cancer Institute

[21] Odense University Hospital,Department of Molecular and Regenerative Medicine

[22] University of Melbourne,Department of Genetics

[23] Department of Preventive and Predictive Medicine,Center for Genomic Medicine, Rigshospitalet

[24] Unit of Molecular Bases of Genetic Risk and Genetic Testing,Department of Oncology, Rigshospitalet

[25] Fondazione IRCCS Istituto Nazionale Tumori (INT),Department of Clinical Genetics, Rigshospitalet

[26] University of Southern California,Institute of Biology and Molecular Genetics

[27] University of Pennsylvania,Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences

[28] Department of Genetics & Computational Biology,Department of Molecular Medicine

[29] Queensland Institute of Medical Research,Clinical Genetics Department

[30] Herston,Department of Clinical Genetics

[31] University of California,Sheffield Clinical Genetics Service

[32] University of Pennsylvania,Department of Clinical Genetics, East Anglian Regional Genetics Service

[33] University of Texas MD Anderson Cancer Center,Leicestershire Clinical Genetics Service

[34] Familial Cancer Centre,Oxford Regional Genetics Service

[35] Peter MacCallum Cancer Centre,Academic Unit of Clinical and Molecular Oncology

[36] University of Melbourne,All Wales Medical Genetics Services

[37] Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute,South East of Scotland Regional Genetics Service

[38] Cedars-Sinai Medical Center,Department of Medical Genetics, Belfast Health and Social Care Trust, Centre for Cancer Research & Cell Biology

[39] Department of Epidemiology,Ferguson

[40] Cancer Prevention Institute of California,Smith Centre for Clinical Genetics

[41] Columbia University,Medical Genetics Unit, St George’s

[42] Fox Chase Cancer Center,Department of Pathology and Laboratory Medicine

[43] University of Utah School of Medicine,Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar

[44] University of Utah School of Medicine,Department of Gynaecology and Obstetrics

[45] Vilnius University Hospital Santariskiu Clinics,Institute of Human Genetics

[46] Hematology,Department of Gynaecology and Obstetrics

[47] Oncology and Transfusion Medicine Center,Institute of Human Genetics

[48] State Research Institute Centre for Innovative Medicine,Laboratoire d’Oncogénétique

[49] Latvian Biomedical Research and Study Centre,INSERM U1052, CNRS UMR5286

[50] Department of Medical Oncology,Centre de Génétique, CHU Dijon

来源：

Breast Cancer Research | / 16卷

关键词：

Breast Cancer; Breast Cancer Risk; Mutation Carrier; Estrogen Receptor Status; Breast Cancer Susceptibility;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

引用

共 147 条

[1]

Mavaddat N(2012)Pathology of breast and ovarian cancers among BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) Cancer Epidemiol Biomarkers Prev 21 134-47

[2]

Barrowdale D(1998)Multifactorial analysis of differences between sporadic breast cancers and cancers involving BRCA1 and BRCA2 mutations J Natl Cancer Inst 90 1138-45

[3]

Andrulis IL(2005)Prediction of BRCA1 status in patients with breast cancer using estrogen receptor and basal phenotype Clin Cancer Res 11 5175-80

[4]

Domchek SM(2003)Repeated observation of breast tumor subtypes in independent gene expression data sets Proc Natl Acad Sci U S A 100 8418-23

[5]

Eccles D(2007)BRCA2 mutation-associated breast cancers exhibit a distinguishing phenotype based on morphology and molecular profiles from tissue microarrays Am J Surg Pathol 31 121-8

[6]

Nevanlinna H(2013)Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk PLoS Genet 9 e1003173-61

[7]

Lakhani SR(2013)Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk PLoS Genet 9 e1003212-8

[8]

Jacquemier J(2013)Large-scale genotyping identifies 41 new loci associated with breast cancer risk Nat Genet 45 353-84

[9]

Sloane JP(2013)Genome-wide association studies identify four ER negative-specific breast cancer risk loci Nat Genet 45 392-84

[10]

Gusterson BA(2013)Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer Nat Genet 45 371-803

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