Find drugs that delay many diseases of old age

被引:52
作者
Bellantuono, Ilaria [1 ]
机构
[1] Univ Sheffield, MRC Arthrit Res UK Ctr Integrated Res Musculoskel, Sheffield, S Yorkshire, England
关键词
SENESCENT CELLS; FRAILTY;
D O I
10.1038/d41586-018-01668-0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Simply extending lifespan is not enough. We need treatments that boost resilience to multiple age-related diseases, argue Ilaria Bellantuono and 12 co-signatories.
引用
收藏
页码:293 / 295
页数:3
相关论文
共 15 条
[1]   Frailty in elderly people [J].
Clegg, Andrew ;
Young, John ;
Iliffe, Steve ;
Rikkert, Marcel Olde ;
Rockwood, Kenneth .
LANCET, 2013, 381 (9868) :752-762
[2]   A Diagnosis of Dismobility-Giving Mobility Clinical Visibility A Mobility Working Group Recommendation [J].
Cummings, Steven R. ;
Studenski, Stephanie ;
Ferrucci, Luigi .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2014, 311 (20) :2061-2062
[3]   With mouse age comes wisdom: A review and suggestions of relevant mouse models for age-related conditions [J].
Drechsler, Susanne ;
Lynch, Marina A. ;
Novella, Susana ;
Gonzalez-Navarro, Herminia ;
Hecimovic, Silva ;
Barini, Erica ;
Tucci, Valter ;
Castro, Rui E. ;
Vandenbroucke, Roosmarijn E. ;
Osuchowski, Marcin ;
Potter, Paul K. .
MECHANISMS OF AGEING AND DEVELOPMENT, 2016, 160 :54-68
[4]   Targeting cellular senescence prevents age-related bone loss in mice [J].
Farr, Joshua N. ;
Xu, Ming ;
Weivoda, Megan M. ;
Monroe, David G. ;
Fraser, Daniel G. ;
Onken, Jennifer L. ;
Negley, Brittany A. ;
Sfeir, Jad G. ;
Ogrodnik, Mikolaj B. ;
Hachfeld, Christine M. ;
LeBrasseur, Nathan K. ;
Drake, Matthew T. ;
Pignolo, Robert J. ;
Pirtskhalava, Tamar ;
Tchkonia, Tamara ;
Oursler, Merry Jo ;
Kirkland, James L. ;
Khosla, Sundeep .
NATURE MEDICINE, 2017, 23 (09) :1072-+
[5]   Interventions for age-related diseases: Shifting the paradigm [J].
Figueira, Ines ;
Fernandes, Adelaide ;
Djordjevic, Aleksandra Mladenovic ;
Lopez-Contreras, Andres ;
Henriques, Catarina M. ;
Selman, Colin ;
Ferreiro, Elisabete ;
Gonos, Efstathios S. ;
Luis Trejo, Jose ;
Misra, Juhi ;
Rasmussen, Lene Juel ;
Xapelli, Sara ;
Ellam, Timothy ;
Bellantuono, Ilaria .
MECHANISMS OF AGEING AND DEVELOPMENT, 2016, 160 :69-92
[6]   Frailty in older adults: Evidence for a phenotype [J].
Fried, LP ;
Tangen, CM ;
Walston, J ;
Newman, AB ;
Hirsch, C ;
Gottdiener, J ;
Seeman, T ;
Tracy, R ;
Kop, WJ ;
Burke, G ;
McBurnie, MA .
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2001, 56 (03) :M146-M156
[7]   Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment [J].
Jeon, Ok Hee ;
Kim, Chaekyu ;
Laberge, Remi-Martin ;
Demaria, Marco ;
Rathod, Sona ;
Vasserot, Alain P. ;
Chung, Jae Wook ;
Kim, Do Hun ;
Poon, Yan ;
David, Nathaniel ;
Baker, Darren J. ;
van Deursen, Jan M. ;
Campisi, Judith ;
Elisseeff, Jennifer H. .
NATURE MEDICINE, 2017, 23 (06) :775-+
[8]   Clinical consequences of polypharmacy in elderly [J].
Maher, Robert L. ;
Hanlon, Joseph ;
Hajjar, Emily R. .
EXPERT OPINION ON DRUG SAFETY, 2014, 13 (01) :57-65
[9]   mTOR inhibition improves immune function in the elderly [J].
Mannick, Joan B. ;
Del Giudice, Giuseppe ;
Lattanzi, Maria ;
Valiante, Nicholas M. ;
Praestgaard, Jens ;
Huang, Baisong ;
Lonetto, Michael A. ;
Maecker, Holden T. ;
Kovarik, John ;
Carson, Simon ;
Glass, David J. ;
Klickstein, Lloyd B. .
SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (268) :268ra179
[10]   Incidence and Predictors of Multimorbidity in the Elderly: A Population-Based Longitudinal Study [J].
Melis, Rene ;
Marengoni, Alessandra ;
Angleman, Sara ;
Fratiglioni, Laura .
PLOS ONE, 2014, 9 (07)