Hyperhomocysteinemia as a risk factor for IUGR

被引：9

作者：

Kiran Pandey

Preeti Dubay

Ajay Bhagoliwal

Neena Gupta

Geetika Tyagi

机构：

[1] Department of Obstetrics and Gynaecology, G.S.V.M. Medical College, Kanpur 208002, Uttar Pradesh

[2] Department of SPM, G.S.V.M. Medical College, Kanpur

来源：

The Journal of Obstetrics and Gynecology of India | 2012年 / 62卷 / 4期

关键词：

Hyperhomocysteinemia; IUGR;

D O I：

10.1007/s13224-012-0287-9

中图分类号：

学科分类号：

摘要：

Objective: To study the role of hyperhomocysteinemia in patients with intrauterine growth retardation. Method 76 patients with intrauterine growth retardation were studied and compared with 50 controls which included pregnant patients without any pregnancy complications. Fasting Plasma homocysteine levels were measured and statistical analysis using tests of significance and logistic regression analysis was performed. Those in the study group were given homocysteine lowering agents for 6 wks and pregnancy outcome was studied. Results: 57.8% women in the study group were found to have hyperhomocysteinemia. Logistic Regression analysis shows an OR of 2.45 in favor of occurrence of IUGR if homocysteine levels are raised which is statistically significant. Mean plasma homocysteine levels decreased after treatment for 6 wks but this decrease in the case of placebo group is marginal whereas the decrease in the homocysteine levels the treatment group. This implies that treatment has a definitive role in lowering of plasma homocysteine levels. Conclusion: The present study shows that hyperhomocysteinemia is associated with IUGR and should be identified as a risk factor as correction favors pregnancy outcome. © 2012 Federation of Obstetric & Gynecological Societies of India.

引用

页码：406 / 408

页数：2

共 6 条

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