Tracing the origins of SARS-COV-2 in coronavirus phylogenies: a review

被引：0
作者：
Erwan Sallard
José Halloy
Didier Casane
Etienne Decroly
Jacques van Helden
机构：
[1] École Normale Supérieure de Paris,
[2] Université de Paris,undefined
[3] CNRS,undefined
[4] LIED UMR 8236,undefined
[5] Université Paris-Saclay,undefined
[6] CNRS,undefined
[7] IRD,undefined
[8] UMR Évolution,undefined
[9] Génomes,undefined
[10] Comportement et Écologie,undefined
[11] Université de Paris,undefined
[12] UFR Sciences du Vivant,undefined
[13] Aix-Marseille Univ,undefined
[14] CNRS,undefined
[15] UMR 7257,undefined
[16] AFMB,undefined
[17] CNRS,undefined
[18] Institut Français de Bioinformatique,undefined
[19] IFB-core,undefined
[20] UMS 3601,undefined
[21] Aix-Marseille Univ,undefined
[22] INSERM,undefined
[23] Lab. Theory and Approaches of Genome Complexity (TAGC),undefined
来源：
Environmental Chemistry Letters | 2021年 / 19卷
关键词：
SARS-CoV-2; Coronavirus; Covid-19; Pandemic; Bioinformatics; Virology; Phylogeny; Genome analysis; Gain of function; Furin; Zoonosis; Biosafety; Spike protein;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
SARS-CoV-2 is a new human coronavirus (CoV), which emerged in China in late 2019 and is responsible for the global COVID-19 pandemic that caused more than 97 million infections and 2 million deaths in 12 months. Understanding the origin of this virus is an important issue, and it is necessary to determine the mechanisms of viral dissemination in order to contain future epidemics. Based on phylogenetic inferences, sequence analysis and structure–function relationships of coronavirus proteins, informed by the knowledge currently available on the virus, we discuss the different scenarios on the origin—natural or synthetic—of the virus. The data currently available are not sufficient to firmly assert whether SARS-CoV2 results from a zoonotic emergence or from an accidental escape of a laboratory strain. This question needs to be solved because it has important consequences on the risk/benefit balance of our interactions with ecosystems, on intensive breeding of wild and domestic animals, on some laboratory practices and on scientific policy and biosafety regulations. Regardless of COVID-19 origin, studying the evolution of the molecular mechanisms involved in the emergence of pandemic viruses is essential to develop therapeutic and vaccine strategies and to prevent future zoonoses. This article is a translation and update of a French article published in Médecine/Sciences, August/September 2020 (https://doi.org/10.1051/medsci/2020123).
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页码：769 / 785
页数：16
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