Suppression of lncRNA HOXA11-AS/miR-124 Axis Inhibits Glioma Progression

被引：0
作者：
Yishan He
Xinguang Qiu
机构：
[1] the First Affiliated Hospital of Zhengzhou University,Department of Breast Surgery
[2] the First Affiliated Hospital of Zhengzhou University,Department of Thyroid Surgery
来源：
Cell Biochemistry and Biophysics | 2021年 / 79卷
关键词：
Glioma; miR-124; lncRNA HOXA11-AS; Cell proliferation; Invasion; Apoptosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Our aim was to clarify the regulations of lncRNA HOXA11-AS (HOXA11-AS) played on the progression of glioma as well as to investigate the mechanisms by which HOXA11-AS modulated development of glioma. This study confirmed the regulations of miR-124 and HOXA11-AS on the progression of glioma. Here, HOXA11-AS was overexpressed and miR-124 was underexpressed in glioma. Expression of miR-124 was negatively related to that of HOXA11-AS. Silencing of HOXA11-AS suppressed cell proliferation, invasion, and promoted apoptosis in glioma cells in vitro. Moreover, inhibition of HOXA11-AS expression repressed glioma xenograft tumor growth. Expression of miR-124 was repressed by HOXA11-AS functioning as sponge. In addition, miR-124 knockdown partially abolished the inhibitory roles of HOXA11-AS downregulation in glioma cells. Conclusively, this study suggested that silencing of HOXA11-AS restrained proliferation, invasion, induced apoptosis of glioma cells, and repressed xenograft growth via modulating miR-124 expression and thus inhibited glioma progression.
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页码：815 / 822
页数：7
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