Sperm cryopreservation and DNA methylation: possible implications for ART success and the health of offspring

被引：0
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作者：
Zahra Khosravizadeh
Kajal Khodamoradi
Zahra Rashidi
Malihe Jahromi
Elham Shiri
Ensieh Salehi
Ali Talebi
机构：
[1] Arak University of Medical Sciences,Clinical Research Development Unit, Amiralmomenin Hospital
[2] University of Miami,Department of Urology
[3] Miller School of Medicine,Department of Anatomical Sciences
[4] School of Medicine,Fertility and Infertility Research Center
[5] Kermanshah University of Medical Sciences,Clinical Research Development Center
[6] Health Technology Institute,Department of Anatomical Sciences
[7] Kermanshah University of Medical Sciences,Fertility and Infertility Research Center
[8] Najafabad Branch,Sexual Health and Fertility Research Center
[9] Islamic Azad University,undefined
[10] School of Medicine,undefined
[11] Hamadan University of Medical Sciences,undefined
[12] Hormozgan University of Medical Sciences,undefined
[13] School of Medicine,undefined
[14] Shahroud University of Medical Sciences,undefined
[15] Shahroud University of Medical Sciences,undefined
来源：
Journal of Assisted Reproduction and Genetics | 2022年 / 39卷
关键词：
Spermatozoa; Cryopreservation; DNA methylation; ROS; ART;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Despite the beneficial effects of sperm cryopreservation, increased reactive oxygen species (ROS) production during this process can affect spermatozoon structure and function. Moreover, ROS production is associated with elevated DNA damage and alterations in DNA methylation. There is little information about the effects of cryopreservation on epigenetic modulation in sperm and the health of children born with frozen spermatozoa. Considering the potential consequences of cryopreservation in ART-conceived children, it is necessary to assure that cryopreservation does not modify sperm DNA methylation status. This review summarizes reports on epigenetic modifications of spermatozoa during cryopreservation and the probable effects of this process on offspring health. Contradictory results have reported the influence of sperm cryopreservation on DNA methylation in imprinted genes. Multiclinical studies with larger sample sizes under the same conditions of cryopreservation and DNA methylation analysis are needed to make any definitive conclusion about the effect of the cryopreservation process on sperm DNA methylation.
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页码：1815 / 1824
页数：9
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