ALDH1A1 and ALDH1A3 paralogues of aldehyde dehydrogenase 1 control myogenic differentiation of skeletal muscle satellite cells by retinoic acid-dependent and -independent mechanisms

被引:0
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作者
Laura Steingruber
Florian Krabichler
Sophie Franzmeier
Wei Wu
Jürgen Schlegel
Marco Koch
机构
[1] University of Augsburg,Anatomy and Cell Biology, Institute of Theoretical Medicine, Faculty of Medicine
[2] Technical University Munich,Department of Neuropathology, Institute of Pathology
[3] Stanford University,Department of Radiology, Molecular Imaging Program at Stanford
来源
Cell and Tissue Research | 2023年 / 394卷
关键词
Myogenic differentiation; ALDH1A1/ALDH1A3 paralogue; CRISPR/Cas9 knock-out; Retinoic acid; Autophagy;
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摘要
ALDH1A1 and ALDH1A3 paralogues of aldehyde dehydrogenase 1 (ALDH1) control myogenic differentiation of skeletal muscle satellite cells (SC) by formation of retinoic acid (RA) and subsequent cell cycle adjustments. The respective relevance of each paralogue for myogenic differentiation and the mechanistic interaction of each paralogue within RA-dependent and RA-independent pathways remain elusive.
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页码:515 / 528
页数:13
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