Exosome-derived circCCAR1 promotes CD8 + T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma

被引：0
作者：
Zongqiang Hu
Gang Chen
Yingpeng Zhao
Hongqiang Gao
Laibang Li
Yanfeng Yin
Jie Jiang
Li Wang
Yuanyi Mang
Yang Gao
Shengning Zhang
Jianghua Ran
Li Li
机构：
[1] First People’s Hospital of Kunming City & Calmette Affiliated Hospital of Kunming Medical University,Department of Hepato
来源：
Molecular Cancer | / 22卷 / 1期
关键词：
circRNA; CCAR1; Hepatocellular carcinoma; Exosome; Anti-PD1;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
[21]   Targeting MMP9 in CTNNB1 mutant hepatocellular carcinoma restores CD8+ T cell-mediated antitumour immunity and improves anti-PD-1 efficacy [J].
Cai, Ning ;
Cheng, Kun ;
Ma, Yue ;
Liu, Sha ;
Tao, Ran ;
Li, Yani ;
Li, Danfeng ;
Guo, Bin ;
Jia, Wenlong ;
Liang, Huifang ;
Zhao, Jianping ;
Xia, Limin ;
Ding, Ze-yang ;
Chen, Jinhong ;
Zhang, Wanguang .
GUT, 2024, 73 (06) :985-999
[22]   Targeting TM4SF1 promotes tumor senescence enhancing CD8+T cell cytotoxic function in hepatocellular carcinoma [J].
Zeng, Weifeng ;
Liu, Furong ;
Liu, Yachong ;
Zhang, Ze ;
Hu, Haofan ;
Ning, Shangwu ;
Zhang, Hongwei ;
Chen, Xiaoping ;
Liao, Zhibin ;
Zhang, Zhanguo .
CLINICAL AND MOLECULAR HEPATOLOGY, 2025, 31 (02)
[23]   Fibrinogen-like protein 1 promotes liver-resident memory T-cell exhaustion in hepatocellular carcinoma [J].
Yang, Changjie ;
Qian, Qiwei ;
Zhao, Yudong ;
Huang, Bingyuan ;
Chen, Ruilin ;
Gong, Qiyu ;
Ji, Hao ;
Wang, Chenchen ;
Xia, Lei ;
You, Zhengrui ;
Zhang, Jianjun ;
Chen, Xiaosong .
FRONTIERS IN IMMUNOLOGY, 2023, 14
[24]   Inhibition of APOC1 promotes the transformation of M2 into M1 macrophages via the ferroptosis pathway and enhances anti-PD1 immunotherapy in hepatocellular carcinoma based on single-cell RNA sequencing [J].
Hao, Xiaopei ;
Zheng, Zhiying ;
Liu, Hanyuan ;
Zhang, Yao ;
Kang, Junwei ;
Kong, Xiangyi ;
Rong, Dawei ;
Sun, Guangshun ;
Sun, Guoqiang ;
Liu, Li ;
Yu, Haibo ;
Tang, Weiwei ;
Wang, Xuehao .
REDOX BIOLOGY, 2022, 56
[25]   S100A9+CD14+ monocytes contribute to anti-PD-1 immunotherapy resistance in advanced hepatocellular carcinoma by attenuating T cell-mediated antitumor function [J].
Xiaoxuan Tu ;
Longxian Chen ;
Yi Zheng ;
Chenglin Mu ;
Zhiwei Zhang ;
Feiyu Wang ;
Yiqing Ren ;
Yingxin Duan ;
Hangyu Zhang ;
Zhou Tong ;
Lulu Liu ;
Xunqi Sun ;
Peng Zhao ;
Lie Wang ;
Xinhua Feng ;
Weijia Fang ;
Xia Liu .
Journal of Experimental & Clinical Cancer Research, 43
[26]   S100A9+CD14+ monocytes contribute to anti-PD-1 immunotherapy resistance in advanced hepatocellular carcinoma by attenuating T cell-mediated antitumor function [J].
Tu, Xiaoxuan ;
Chen, Longxian ;
Zheng, Yi ;
Mu, Chenglin ;
Zhang, Zhiwei ;
Wang, Feiyu ;
Ren, Yiqing ;
Duan, Yingxin ;
Zhang, Hangyu ;
Tong, Zhou ;
Liu, Lulu ;
Sun, Xunqi ;
Zhao, Peng ;
Wang, Lie ;
Feng, Xinhua ;
Fang, Weijia ;
Liu, Xia .
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2024, 43 (01)
[27]   PD1Hi CD8+ T cells correlate with exhausted signature and poor clinical outcome in hepatocellular carcinoma [J].
Jiaqiang ;
Zheng, Bohao ;
Goswami, Shyamal ;
Meng, Lu ;
Zhang, Dandan ;
Cao, Chunmei ;
Li, Teng ;
Zhu, Fangming ;
Ma, Lijie ;
Zhang, Zhao ;
Zhang, Shuhao ;
Duan, Meng ;
Chen, Qin ;
Gao, Qiang ;
Zhang, Xiaoming .
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7 (01)
[28]   Glycolysis regulated exosomal LINC01214 inhibited CD8+ T cell function and induced anti-PD1 resistance in melanoma via modulating miR-4492/ PPP1R11 axis [J].
Ding, Zhi ;
Wu, Baojin ;
Yang, Junyi ;
Wang, Daohe ;
Qiao, Jing ;
Guo, Fanli .
NON-CODING RNA RESEARCH, 2025, 10 :242-251
[29]   S100A9 promotes resistance to anti-PD-1 immunotherapy in hepatocellular carcinoma by degrading PARP1 and activating the STAT3/PD-L1 pathway [J].
Zhou, Xianwei ;
Qiao, Chu ;
Chu, Xuehui ;
Yang, Yajing ;
Man, Haoran ;
Liu, Jingxin ;
Li, Yunzheng ;
Xu, Zhu ;
Li, Huan ;
Shan, Xiaodong ;
Lian, Zaowu ;
Lu, Yanjun ;
Wang, Weihong ;
Yu, Decai ;
Sun, Xitai ;
Li, Binghua .
CELLULAR ONCOLOGY, 2025,
[30]   CD36 promotes iron accumulation and dysfunction in CD8+T cells via the p38-CEBPB-TfR1 axis in early-stage hepatocellular carcinoma [J].
Qin, Yifei ;
Huo, Fei ;
Feng, Zhuan ;
Hou, Jialu ;
Ding, Yaxin ;
Wang, Quancheng ;
Gui, Yu ;
Yang, Ziwei ;
Yang, Jiali ;
Zhou, Gang ;
Li, Ling ;
Jiang, Jianli ;
Kong, Lingmin ;
Wang, Shijie ;
Nan, Gang ;
Xu, Dingqiao ;
Xie, Xiaohang ;
Wang, Lijuan ;
He, Qian ;
Yang, Ruibin ;
Lin, Peng ;
Bian, Huijie ;
Chen, Zhi-Nan ;
Wu, Jiao .
CLINICAL AND MOLECULAR HEPATOLOGY, 2025, 31 (03)
12345