Epigenome-wide DNA methylation profiling of periprostatic adipose tissue in prostate cancer patients with excess adiposity—a pilot study

被引：0
作者：
Yan Cheng
Cátia Monteiro
Andreia Matos
Jiaying You
Avelino Fraga
Carina Pereira
Victoria Catalán
Amaia Rodríguez
Javier Gómez-Ambrosi
Gema Frühbeck
Ricardo Ribeiro
Pingzhao Hu
机构：
[1] University of Manitoba,Department of Biochemistry and Medical Genetics & Department of Electrical and Computer Engineering
[2] Northwest University for Nationalities,Experimental Center
[3] Portuguese Institute of Oncology,Molecular Oncology Group
[4] Portuguese League Against Cancer–North,Research Department
[5] University of Lisboa,Laboratory of Genetics and Environmental Health Institute, Faculty of Medicine
[6] University of Porto,Tumor & Microenvironment Interactions, i3S/INEB, Institute for Research and Innovation in Health, and Institute of Biomedical Engineering
[7] Centro Hospitalar Universitário do Porto,Department of Urology
[8] CINTESIS,Metabolic Research Laboratory
[9] Center for Health Technology and Services Research,Department of Endocrinology
[10] Faculty of Medicine,Department of Clinical Pathology
[11] e,undefined
[12] University of Porto,undefined
[13] Universidad de Navarra,undefined
[14] CIBER Fisiopatología de la Obesidad y Nutricion,undefined
[15] Instituto de Salud Carlos III,undefined
[16] Clínica Universidad de Navarra,undefined
[17] Centro Hospitalar e Universitário de Coimbra,undefined
[18] i3S/INEB,undefined
[19] Instituto de Investigação e Inovação em Saúde/Instituto Nacional de Engenharia Biomédica,undefined
[20] Universidade do Porto,undefined
[21] Tumor & Microenvironment Interactions,undefined
来源：
Clinical Epigenetics | 2018年 / 10卷
关键词：
DNA methylation; Periprostatic adipose tissue; Obesity; Prostate cancer; Microenvironment;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 536 条
  • [1] Labbé DP(2014)Role of diet in prostate cancer: the epigenetic link Oncogene 34 4683-4691
  • [2] Zadra G(2013)Prostate cancer: is it time to expand the research focus to early-life exposures? Nat Rev Cancer 13 208-218
  • [3] Ebot EM(2017)Prostate cancer progression and mortality: a review of diet and lifestyle factors World J Urol 35 867-874
  • [4] Mucci LA(2012)Obesity and prostate cancer: gene expression signature of human periprostatic adipose tissue BMC Med 10 108-335
  • [5] Kantoff PW(2014)Periprostatic adipose tissue from obese prostate cancer patients promotes tumor and endothelial cell proliferation: a functional and MR imaging pilot study Prostate 74 326-657
  • [6] Loda M(2015)MRS measured fatty acid composition of periprostatic adipose tissue correlates with pathological measures of prostate cancer aggressiveness J Magn Reson Imaging 42 651-36
  • [7] Brown M(2016)Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity Nat Commun 7 10230-20
  • [8] Sutcliffe S(2012)Human periprostatic adipose tissue promotes prostate cancer aggressiveness in vitro J Exp Clin Cancer Res 31 32-8900
  • [9] Colditz GA(2008)Gene-environment interactions and epigenetic basis of human diseases Curr Issues Mol Biol 10 25-63
  • [10] Peisch SF(2009)DNA methylation: an introduction to the biology and the disease-associated changes of a promising biomarker Methods Mol Biol 507 3-258
12345678910