Prevalence and patterns of soft tissue metastasis: Detection with true whole-body F-18 FDG PET/CT

被引：53
作者：
Nguyen N.C. [1 ]
Chaar B.T. [2 ]
Osman M.M. [1 ]
机构：
[1] Division of Nuclear Medicine, Department of Radiology, Saint Louis University Hospital, St. Louis, MO
[2] Division of Hematology and Oncology, Department of Internal Medicine, Saint Louis University Hospital, St. Louis, MO
来源：
BMC Medical Imaging | / 7卷 / 1期
关键词：
Melanoma Patient; Actinic Keratosis; Soft Tissue Lesion; Soft Tissue Metastasis; Subcutaneous Lesion;
D O I：
10.1186/1471-2342-7-8
中图分类号：
学科分类号：
摘要：
Background: The aim of this retrospective study was to report the prevalence and patterns of soft tissue (ST) metastasis detected with true whole-body (TWB) F-18 FDG PET/CT acquired from the top of the skull through the bottom of the feet and to compare such findings to that of the typically acquired skull-base to upper-thigh, thus limited whole-body (LWB) field of view (FOV). Methods: TWB FDG-PET/CT scans were performed in 500 consecutive cancer patients. Suspected ST metastasis was verified by correlation with surgical pathology, other imaging modalities, or clinical follow-up. Results: Nine out of 500 patients (1.8%) had ST metastasis with a prevalence of 4/41 (9.8%) for melanoma, 2/60 (3.3%) for lung carcinoma, 2/88 (2.3%) for lymphoma and 1/13 (77%) for esophageal cancer. Those nine patients had a total of 41 ST lesions: 22 lesions within and 19 outside of LWB FOV. Of those 41 lesions, 19 (46%) were subcutaneous and 22 (54%) were muscular lesions. The presence of ST metastasis neither changed the staging nor the treatment in any of these patients. However, the ST lesions provided a biopsy site in 4 of the 9 patients (44%). Seven out of nine studied patients died of their disease within 1-22 months after ST metastasis was diagnosed. Conclusion: The detection of ST metastasis may have prognostic implications, provide more accessible biopsy sites and help avoid invasive procedures. A LWB scanning may underestimate the true extent of ST metastasis since a significant percentage of ST metastasis (46%) occurred outside the typical LWB FOV. © 2007 Nguyen et al; licensee BioMed Central Ltd.
引用
收藏
相关论文
共 24 条
[1]  
Spencer P.S., Helm T.N.L., Skin metastasis in cancer patients, Cutis, 39, pp. 119-121, (1987)
[2]  
Lookingbill D.P., Spangler N., Sexton F.M., Skin involvement as the presenting sign of internal carcinoma. A retrospective study of 7316 cancer patients, J Am Acad Dermatol, 22, 1, pp. 19-26, (1990)
[3]  
Hidaka T., Ischii Y., Kitamura S., Clinical features of skin metastasis from lung cancer, Intern Med, 35, 6, pp. 459-462, (1996)
[4]  
Czernin J., Allen-Auerbach M., Schelbert H.R., Improvements in cancer staging with PET/CT: Literature-based evidence as of September 2006, J Nucl Med, 48, SUPPL. 1, (2007)
[5]  
Von Schulthess G.K., Steinert H.C., Hany T.F., Integrated PET/CT: Current Applications and Future Directions, Radiology, 238, pp. 405-422, (2006)
[6]  
Delbeke D., Coleman R.E., Guiberteau M.J., Procedure guideline for tumor imaging with 18F-FDG PET/CT 1.0, JNM, 47, 5, pp. 885-895, (2006)
[7]  
Browne J., De Pierro A., A row-action alternative to the EM algorithm for maximizing likelihoods in emission tomography, IEEE Trans Med Imag, 15, pp. 687-699, (1996)
[8]  
Damron T.A., Heiner J., Distant soft tissue metastasis: A series of 30 new patients and 91 cases from the literature, Ann Surg Oncol, 7, pp. 526-534, (2000)
[9]  
Balch C.M., Buzaid A.C., Soong S.J., Atkins M.B., Cascinelli N., Coit D.G., Fleming I.D., Gershenwald J.E., Houghton Jr. A., Kirkwood J.M., McMasters K.M., Mihm M.F., Morton D.L., Reintgen D.S., Ross M.I., Sober A., Thompson J.A., Thompson J.F., Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma, J Clin Oncol, 19, (2001)
[10]  
Balch C.M., Soong S.J., Gershenwald J.E., Thompson J.F., Reintgen D.S., Cascinelli N., Urist M., McMasters K.M., Ross M.I., Kirkwood J.M., Atkins M.B., Thompson J.A., Coit D.G., Byrd D., Desmond R., Zhang Y., Liu P.Y., Lyman G.H., Morabito A., Prognostic factors analysis of 17,600 melanoma patients: Validation of the American Joint Committee on Cancer melanoma staging system, J Clin Oncol, 19, (2001)
123