Vascular compliance in diabetes

被引：17
作者：
Nathaniel Winer
James R. Sowers
机构：
[1] SUNY Downstate Medical Center,Division of Endocrinology, Diabetes, and Hypertension
来源：
Current Diabetes Reports | 2003年 / 3卷 / 3期
关键词：
Nitric Oxide; Pulse Pressure; Arterial Stiffness; Pulse Wave Velocity; Arterial Compliance;
D O I：
10.1007/s11892-003-0069-y
中图分类号：
学科分类号：
摘要：
The measurement of vascular compliance has assumed increasing importance as a powerful predictor of cardiovascular and all-cause mortality. Arterial stiffness increases with the duration of diabetes, older age, and concomitant hypertension. Hyperglycemia may increase arterial stiffness in diabetes by reducing the bioactivity of endothelium-derived nitric oxide (NO) either by decreasing NO production or inactivating NO by interaction with oxygen-derived free radicals. New approaches to therapy, such as the use of advanced glycation end product "breakers," may potentially benefit patients with diabetes.
引用
收藏
页码：230 / 234
页数：4
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