Discriminating infectious meningitis versus neuropsychiatric involvement in patients with systemic lupus erythematosus: a single-center experience

被引:0
作者
Jinyun Chen
Xuebing Feng
Hong Wang
Bingzhu Hua
Congzhu Ding
Bujun Liu
Lingyun Sun
机构
[1] Nanjing University Medical School,Department of Rheumatology, The Affiliated Drum Tower Hospital
[2] Nanjing University Medical School,Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital
来源
Clinical Rheumatology | 2015年 / 34卷
关键词
Central nervous system infection; Neuropsychiatric lupus; Systemic lupus erythematosus;
D O I
暂无
中图分类号
学科分类号
摘要
The objective of this study is to identify the clinical differences between infectious meningitis and neuropsychiatric systemic lupus erythematosus (NPSLE) in patients with SLE. Clinical manifestations, laboratory test results, and prognoses of 14 SLE patients complicated with various infectious meningitis, hospitalized in the Affiliated Drum Tower Hospital of Nanjing University Medical School in the past 7 years, were reviewed and compared with those of 34 concomitantly treated NPSLE patients. Our study shows that mortality rate was much higher in SLE patients with infectious meningitis than in NPSLE patients. Compared to NPSLE, those with infectious meningitis had lower SLE Disease Activity Index (SLEDAI), but higher doses of corticosteroids 1 month before the occurrence of CNS symptoms. Headache, high fever, and vomiting were more common in patients with infectious meningitis, accompanied with the elevation of C-reactive protein level. Cerebrospinal fluid (CSF) examination showed increased levels of leukocytes and proteins but decreased glucose level in patients with infectious meningitis. We conclude that for SLE patients exhibiting CNS symptoms, high fever, high intake of corticosteroids, and abnormal CSF are important clues for the coexistence of infectious meningitis, especially tuberculous meningitis.
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页码:365 / 369
页数:4
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