Unusual formation of N-hydroxy-3,3-dimethyl-2,6-diarylpiperidin-4-one and its thiosemicarbazide derivative - Synthesis and antimicrobial activity

被引：0

作者：

Gopalakrishnan M. ^{[1
]}

Sureshkumar P. ^{[1
]}

Thanusu J. ^{[1
]}

Kanagarajan V. ^{[1
]}

机构：

[1] Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University, Annamalainagar-608 002, Tamil Nadu

来源：

Pharmaceutical Chemistry Journal | 2008年 / 42卷 / 5期

关键词：

Antifungal Activity; Thiosemicarbazone; Thiosemicarbazide; Shigella Flexneri; Ciclopirox;

D O I：

10.1007/s11094-008-0104-z

中图分类号：

学科分类号：

摘要：

A series of novel N-hydroxy-3,3-dimethyl-2,6-diarylpiperidin-4-one thiosemicarbazones 28-32 is synthesized, characterized by melting point, elemental analysis, and MS, FT-IR, NMR (1H & 13C) spectroscopic data and evaluated for their in vitro antibacterial and antifungal activities. Of all the compounds synthesized, compound 31 exerted a wide range of antibacterial activities against the entire tested gram-positive and gram-negative bacterial strains except Escherichia coli. Compound 31 exerted strong antifungal activities against Aspergillus flavus, Mucor, and Microsporum gypseum. © 2008 Springer Science+Business Media, Inc.

引用

页码：271 / 276

页数：5

共 16 条

[1] Unusual Formation of N-hydroxy-3,3-dimethyl-2,6-diarylpiperidin-4-one and its Thiosemicarbazide Derivative-Synthesis and Antimicrobial Activity
Gopalakrishnan, M.
Sureshkumar, P.
Thanusu, J.
Kanagarajan, V.
JOURNAL OF THE KOREAN CHEMICAL SOCIETY-DAEHAN HWAHAK HOE JEE, 2008, 52 (05): : 503 - 510
[2] Unusual formation of N-Hydroxy-3,3-dimethyl-2,6-diarylpiperidin-4-one and its thiosemicarbazide derivative-synthesis and antimicrobial activity
Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University, Annamalainagar-608 002 Tamil Nadu, India
J. Korean Chem. Soc., 2008, 5 (503-510):
[3] Strange formation of N-hydroxy-3,3-dimethyl-2,6-diarylpiperidin-4-one and its oxime derivative - Synthesis, stereochemistry, antibacterial and antifungal activity
Kanagarajan, V.
Sureshkumar, P.
Gopalakrishnan, M.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2010, 14 (07) : 597 - 604
[4] Design and synthesis of novel piperazine unit condensed 2,6-diarylpiperidin-4-one derivatives as antituberculosis and antimicrobial agents
Mannangatty Rani
Paramasivam Parthiban
Rajamanickam Ramachandran
Senthamaraikannan Kabilan
Medicinal Chemistry Research, 2012, 21 : 653 - 662
[5] Synthesis, stereochemical, structural and biological studies of some 2,6-diarylpiperidin-4-one N(4′)-cyclohexyl thiosemicarbazones
Sethukumar, A.
Kumar, C. Udhaya
Agilandeshwari, R.
Prakasam, B. Arul
JOURNAL OF MOLECULAR STRUCTURE, 2013, 1047 : 237 - 248
[6] Design and synthesis of novel piperazine unit condensed 2,6-diarylpiperidin-4-one derivatives as antituberculosis and antimicrobial agents
Rani, Mannangatty
Parthiban, Paramasivam
Ramachandran, Rajamanickam
Kabilan, Senthamaraikannan
MEDICINAL CHEMISTRY RESEARCH, 2012, 21 (05) : 653 - 662
[7] Synthesis, antibacterial and antifungal activities of some N-nitroso-2,6-diarylpiperidin-4-one semicarbazones and QSAR analysis
Hemalatha, T.
Imran, P. K. M.
Gnanamani, A.
Nagarajan, S.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2008, 19 (04): : 303 - 311
[8] Cyclic voltametric study of some alkyl substituted N-hydroxy-2,6-diarylpiperidin-4-one semicarbazone and the antibacterial studies of the products
Veeramalini, J. B.
Baskar, G.
Sheeja, N.
INTERNATIONAL JOURNAL OF MATERIALS & PRODUCT TECHNOLOGY, 2017, 55 (1-3): : 93 - 112
[9] Environmentally benign one-pot synthesis and antimicrobial activity of 1-methyl-2,6-diarylpiperidin-4-ones
Nithya, Pattusamy
Khan, Fazlur-Rahman Nawaz
Roopan, Selvaraj Mohana
Shankar, Uma
Jin, Jong Sung
CHEMICAL PAPERS, 2011, 65 (05) : 743 - 746
[10] Environmentally benign one-pot synthesis and antimicrobial activity of 1-methyl-2,6-diarylpiperidin-4-ones
Pattusamy Nithya
Fazlur-Rahman Nawaz Khan
Selvaraj Mohana Roopan
Uma Shankar
Jong Sung Jin
Chemical Papers, 2011, 65 : 743 - 746

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