The Netherlands study of depression in older persons (NESDO); A prospective cohort study

被引：144
作者：
Comijs H.C. [1 ,15 ]
Van Marwijk H.W. [2 ]
Van Der Mast R.C. [3 ]
Naarding P. [4 ]
Oude Voshaar R.C. [5 ,6 ]
Beekman A.T.F. [7 ]
Boshuisen M. [8 ]
Dekker J. [9 ]
Kok R. [10 ]
De Waal M.W.M. [11 ]
Penninx B.W.J.H. [12 ]
Stek M.L. [13 ]
Smit J.H. [14 ]
机构：
[1] Department Psychiatry, EMGO Institute for Health and Care Research, VU University Medical Center/GGZinGeest, Amsterdam
[2] Department of General Practice, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam
[3] Department of Psychiatry, Leiden University Medical Center, Leiden
[4] Department of Old-age Psychiatry, GGNet, Apeldoorn/Zutphen
[5] University Center of Psychiatry, Interdisciplinary Center of Psychiatric Epidemiology, University Medical Center Groningen, Groningen
[6] Department of Psychiatry, Radboud University, Nijmegen Medical Center, Nijmegen
[7] Department Psychiatry, EMGO Institute for Health and Care Research, VU University, Amsterdam
[8] Lentis Dignis, Groningen
[9] Department of General Practice, University Medical Center Groningen, Groningen
[10] Department of Old-age Psychiatry, Parnassia/BAVO Groep, The Hague
[11] Department of Public Health and Primary Care, Leiden University Medical Center, Leiden
[12] Department Psychiatry, EMGO Institute for Health and Care Research, Medical Center, Amsterdam
[13] Department of Old-age Psychiatry, GGZinGeest, Amsterdam
[14] Department Psychiatry, EMGO Institute for Health and Care Research, Institute for Neurosciences, Amsterdam
[15] Department Psychiatry, VUMC, 1081 HL Amsterdam
来源：
BMC Research Notes | / 4卷 / 1期
关键词：
Anxiety Disorder; Respiratory Sinus Arrhythmia; Depressed Person; Computer Assist Personal Interview; Netherlands Study;
D O I：
10.1186/1756-0500-4-524
中图分类号：
学科分类号：
摘要：
Background: To study late-life depression and its unfavourable course and co morbidities in The Netherlands. Methods. We designed the Netherlands Study of Depression in Older Persons (NESDO), a multi-site naturalistic prospective cohort study which makes it possible to examine the determinants, the course and the consequences of depressive disorders in older persons over a period of six years, and to compare these with those of depression earlier in adulthood. Results: From 2007 until 2010, the NESDO consortium has recruited 510 depressed and non depressed older persons ( 60 years) at 5 locations throughout the Netherlands. Depressed persons were recruited from both mental health care institutes and general practices in order to include persons with late-life depression in various developmental and severity stages. Non-depressed persons were recruited from general practices. The baseline assessment included written questionnaires, interviews, a medical examination, cognitive tests and collection of blood and saliva samples. Information was gathered about mental health outcomes and demographic, psychosocial, biological, cognitive and genetic determinants. The baseline NESDO sample consists of 378 depressed (according to DSM-IV criteria) and 132 non-depressed persons aged 60 through 93 years. 95% had a major depression and 26.5% had dysthymia. Mean age of onset of the depressive disorder was around 49 year. For 33.1% of the depressed persons it was their first episode. 41.0% of the depressed persons had a co morbid anxiety disorder. Follow up assessments are currently going on with 6 monthly written questionnaires and face-to-face interviews after 2 and 6 years. Conclusions: The NESDO sample offers the opportunity to study the neurobiological, psychosocial and physical determinants of depression and its long-term course in older persons. Since largely similar measures were used as in the Netherlands Study of Depression and Anxiety (NESDA; age range 18-65 years), data can be pooled thus creating a large longitudinal database of clinically depressed persons with adequate power and a large set of neurobiological, psychosocial and physical variables from both younger and older depressed persons. © 2011 Comijs et al; licensee BioMed Central Ltd.
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