Behavioral Differences Between C57BL/6J × FVB/NJ and C57BL/6J × NZB/B1NJ F1 Hybrid Mice: Relation to Control of Ethanol Intake

被引：0
作者：
A. R. Ozburn
R. A. Harris
Y. A. Blednov
机构：
[1] University of Texas at Austin,Waggoner Center for Alcoholism and Addiction Research, Institute for Neuroscience
来源：
Behavior Genetics | 2010年 / 40卷
关键词：
Alcohol preference or consumption; Hybrid; Conditioned place preference; Conditioned taste aversion; Loss of righting reflex;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
C57BL/6J × FVB/NJ F1 (B6 × FVB) mice consume more alcohol than C57BL/6J × NZB/B1NJ F1 (B6 × NZB) mice and this high alcohol consumption is stable after abstinence whereas B6 × NZB show reduced consumption, thus providing models of Sustained Alcohol Preference (SAP) and Reduced Alcohol Preference (RAP). In female hybrids, we assessed several behavioral responses to define behaviors which might predict SAP and RAP. B6 × FVB exhibited less severe ethanol-induced conditioned taste aversion and were less sensitive to ethanol-induced loss of righting reflex than B6 × NZB. Both hybrids demonstrated ethanol-induced place preference and a low ethanol withdrawal severity. We found that these hybrids differ in their sensitivity to the aversive and sedative, but not rewarding, effects of ethanol. Results of elevated plus maze, mirror chamber, and locomotor tests reveal B6 × FVB mice are less anxious and more active than B6 × NZB mice. Results obtained offer insights about factors that determine SAP and RAP in these new genetic models of alcohol consumption.
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页码：551 / 563
页数：12
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