One test for all: whole exome sequencing significantly improves the diagnostic yield in growth retarded patients referred for molecular testing for Silver–Russell syndrome

被引:0
作者
Robert Meyer
Matthias Begemann
Christian Thomas Hübner
Daniela Dey
Alma Kuechler
Magdeldin Elgizouli
Ulrike Schara
Laima Ambrozaityte
Birute Burnyte
Carmen Schröder
Asmaa Kenawy
Peter Kroisel
Stephanie Demuth
Gyorgy Fekete
Thomas Opladen
Miriam Elbracht
Thomas Eggermann
机构
[1] RWTH Aachen University,Institute of Human Genetics, Medical Faculty
[2] University Duisburg-Essen,Institute of Human Genetics, University Hospital Essen
[3] University Duisburg-Essen,Department of Neuropediatrics, University Children’s Hospital
[4] Vilnius University,Department of Human and Medical Genetics, Institute of Biomedical Sciences, Faculty of Medicine
[5] Universitätsmedizin Greifswald,Zentrum Für Kinder
[6] Alexandria University, Und Jugendmedizin, Abt. Allgemeine Pädiatrie
[7] Institute of Human Genetics,Department of Human Genetics, Medical Research Institute
[8] Praxis Für Humangenetik,II. Department of Pediatrics
[9] Semmelweis University,Division for Child Neurology and Metabolic Medicine
[10] University Children’s Hospital Heidelberg,undefined
来源
Orphanet Journal of Rare Diseases | / 16卷
关键词
Silver–Russell syndrome; Next generation sequencing; Diagnostic detection rate; Whole exome sequencing; Targeted multigene panel NGS;
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