One test for all: whole exome sequencing significantly improves the diagnostic yield in growth retarded patients referred for molecular testing for Silver–Russell syndrome

被引:0
作者
Robert Meyer
Matthias Begemann
Christian Thomas Hübner
Daniela Dey
Alma Kuechler
Magdeldin Elgizouli
Ulrike Schara
Laima Ambrozaityte
Birute Burnyte
Carmen Schröder
Asmaa Kenawy
Peter Kroisel
Stephanie Demuth
Gyorgy Fekete
Thomas Opladen
Miriam Elbracht
Thomas Eggermann
机构
[1] RWTH Aachen University,Institute of Human Genetics, Medical Faculty
[2] University Duisburg-Essen,Institute of Human Genetics, University Hospital Essen
[3] University Duisburg-Essen,Department of Neuropediatrics, University Children’s Hospital
[4] Vilnius University,Department of Human and Medical Genetics, Institute of Biomedical Sciences, Faculty of Medicine
[5] Universitätsmedizin Greifswald,Zentrum Für Kinder
[6] Alexandria University, Und Jugendmedizin, Abt. Allgemeine Pädiatrie
[7] Institute of Human Genetics,Department of Human Genetics, Medical Research Institute
[8] Praxis Für Humangenetik,II. Department of Pediatrics
[9] Semmelweis University,Division for Child Neurology and Metabolic Medicine
[10] University Children’s Hospital Heidelberg,undefined
来源
Orphanet Journal of Rare Diseases | / 16卷
关键词
Silver–Russell syndrome; Next generation sequencing; Diagnostic detection rate; Whole exome sequencing; Targeted multigene panel NGS;
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[1]  
Azzi S(2015)A prospective study validating a clinical scoring system and demonstrating phenotypical-genotypical correlations in Silver-Russell syndrome J Med Genet 52 446-453
[2]  
Salem J(2017)Diagnosis and management of Silver–Russell syndrome: first international consensus statement Nat Rev Endocrinol 13 105-124
[3]  
Thibaud N(2018)Structural and sequence variants in patients with Silver–Russell syndrome or similar features-Curation of a disease database Hum Mutat 39 345-364
[4]  
Chantot-Bastaraud S(2013)CDKN1C mutation affecting the PCNA-binding domain as a cause of familial Russell–Silver syndrome J Med Genet 50 823-830
[5]  
Lieber E(2015)Paternally inherited IGF2 mutation and growth restriction N Engl J Med 373 349-356
[6]  
Netchine I(2017)Targeted next generation sequencing approach in patients referred for Silver–Russell syndrome testing increases the mutation detection rate and provides decisive information for clinical management J Pediatr 187 206-212
[7]  
Harbison MD(2019)Next generation sequencing and imprinting disorders: current applications and future perspectives: lessons from Silver–Russell syndrome Mol Cell Probes 44 1-7
[8]  
Wakeling EL(2015)Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology Genet Med 17 405-424
[9]  
Brioude F(2016)EMQN best practice guidelines for the molecular genetic testing and reporting of chromosome 11p15 imprinting disorders: Silver–Russell and Beckwith–Wiedemann syndrome Eur J Hum Genet 24 1377-1387
[10]  
Lokulo-Sodipe O(2009)Multilocus methylation analysis in a large cohort of 11p15-related foetal growth disorders (Russell Silver and Beckwith Wiedemann syndromes) reveals simultaneous loss of methylation at paternal and maternal imprinted loci Hum Mol Genet 18 4724-4733