Autophagy and Alzheimer’s Disease

被引：0
作者：
Qian Li
Yi Liu
Miao Sun
机构：
[1] Peking University,Neuroscience Research Institute
[2] Affiliated Hospital of Dalian Medical University,Department of Neurology, Dalian Municipal Central Hospital
[3] Rutgers University,Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School
来源：
Cellular and Molecular Neurobiology | 2017年 / 37卷
关键词：
Autophagy; β-Amyloid; Tau; Alzheimer’s disease;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Autophagy is an essential degradation pathway in clearing abnormal protein aggregates in mammalian cells and is responsible for protein homeostasis and neuronal health. Several studies have shown that autophagy deficits occurred in early stage of Alzheimer’s disease (AD). Autophagy plays an important role in generation and metabolism of β-amyloid (Aβ), assembling of tau and thus its malfunction may lead to the progress of AD. By considering the above evidences, autophagy may be a new target in developing drugs for AD. So far, a number of mammalian target of rapamycin (mTOR)-dependent and independent autophagy modulators have been identified to have positive effects in AD treatment. In this review, we summarized the latest progress supporting the role for autophagy deficits in AD and the potential therapeutic effects of autophagy modulators in AD.
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页码：377 / 388
页数：11
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