Update on the risk of hepatocellular carcinoma in chronic hepatitis B virus infection

被引：9
作者：
Hsu A. [1 ]
Lai C.-L. [1 ]
Yuen M.-F. [1 ]
机构：
[1] Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pok Fu Lam, Pokfulam Road
来源：
Current Hepatitis Reports | 2011年 / 10卷 / 2期
关键词：
Hepatitis B virus; Hepatocellular carcinoma; Mutation; Risk factors; Risk prediction;
D O I：
10.1007/s11901-011-0094-2
中图分类号：
学科分类号：
摘要：
Chronic hepatitis B virus infection is an important cause of liver-related morbidity and mortality, with hepatocellular carcinoma being the most life-threatening complication. Because of the highly variable clinical course of the disease, enormous research efforts have been made with the aim of revealing the factors in the natural history that are relevant to hepatocarcinogenesis. These include epidemiological studies of predisposing risk groups, viral studies of mutations within the hepatitis B viral genome, and clinical correlation of these risk factors in predicting the likelihood of development of hepatocellular cancer in susceptible hosts. This update addresses these risks, with emphasis on the latest research relevant to hepatocarcinogenesis. © 2011 The Author(s).
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页码：106 / 111
页数：5
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