SALL4 promotes angiogenesis in gastric cancer by regulating VEGF expression and targeting SALL4/VEGF pathway inhibits cancer progression

被引：0
|
作者：
Fatma A. Abouelnazar
Xiaoxin Zhang
Jiahui Zhang
Maoye Wang
Dan Yu
Xueyan Zang
Jiayin Zhang
Yixin Li
Jing Xu
Qiurong Yang
Yue Zhou
Haozhou Tang
Yanzheng Wang
Jianmei Gu
Xu Zhang
机构：
[1] Jiangsu University,Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine
[2] Affiliated Cancer Hospital of Nantong University,Department of Clinical Laboratory Medicine
来源：
Cancer Cell International | / 23卷
关键词：
Gastric cancer; Angiogenesis; SALL4; VEGF; CRISPR/Cas9; Thalidomide; Exosomes;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [11] SALL4 activates TGF-β/SMAD signaling pathway to induce EMT and promote gastric cancer metastasis
    Zhang, Xu
    Zhang, Peng
    Shao, Meng
    Zang, Xueyan
    Zhang, Jiayin
    Mao, Fei
    Qian, Hui
    Xu, Wenrong
    CANCER MANAGEMENT AND RESEARCH, 2018, 10 : 4459 - 4470
  • [12] HOXC12 promotes the invasion and migration of gastric cancer cells by upregulating SALL4 and activating Wnt/β-catenin signaling pathway
    Zhang, Jun
    Hou, Nengbin
    Rao, Dewang
    Chen, Qian
    Ning, Zhongliang
    Lu, Ming
    DISCOVER ONCOLOGY, 2024, 15 (01)
  • [13] The Expression and Prognostic Significance of VEGF and CXCR4 in Gastric Cancer: Correlation with Angiogenesis, Lymphangiogenesis and Progression
    Kruszyna, Lukasz
    Murawa, Dawid
    Jagodzinski, Pawel Piotr
    Oszkinis, Grzegorz
    Krasinski, Zbigniew
    CURRENT ISSUES IN MOLECULAR BIOLOGY, 2022, 44 (07) : 3075 - 3088
  • [14] Dual-Regulated Mechanism of EZH2 and KDM6A on SALL4 Modulates Tumor Progression via Wnt/β-Catenin Pathway in Gastric Cancer
    Lei Ren
    Hong Deng
    Yu Jiang
    Chunfeng Liu
    Digestive Diseases and Sciences, 2023, 68 : 1292 - 1305
  • [15] Dual-Regulated Mechanism of EZH2 and KDM6A on SALL4 Modulates Tumor Progression via Wnt/β-Catenin Pathway in Gastric Cancer
    Ren, Lei
    Deng, Hong
    Jiang, Yu
    Liu, Chunfeng
    DIGESTIVE DISEASES AND SCIENCES, 2023, 68 (04) : 1292 - 1305
  • [16] CXCR4 is a prognostic marker that inhibits the invasion and migration of gastric cancer by regulating VEGF expression
    Chen, Gaoyang
    Zhou, Zhen
    Jin, Jun
    Zhou, Yan
    Liu, Yanqing
    Wang, Weimin
    ONCOLOGY LETTERS, 2021, 22 (02)
  • [17] miR-188-5p emerges as an oncomiRNA to promote gastric cancer cell proliferation and migration via upregulation of SALL4
    Wang, Mei
    Qiu, Rong
    Gong, Zheng
    Zhao, Xinxin
    Wang, Tingting
    Zhou, Lulu
    Lu, Weiwei
    Shen, Bo
    Zhu, Wei
    Xu, Wenrong
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2019, 120 (09) : 15027 - 15037
  • [18] High cytoplasmic expression of SALL4 predicts a malignant phenotype and poor prognosis of breast invasive ductal carcinoma
    Yue, X.
    Xiao, L.
    Yang, Y.
    Liu, W.
    Zhang, K.
    Shi, G.
    Zhou, H.
    Geng, J.
    Ning, X.
    Wu, J.
    Zhang, Q.
    NEOPLASMA, 2015, 62 (06) : 980 - 987
  • [19] Cathepsin L promotes angiogenesis by regulating the CDP/Cux/VEGF-D pathway in human gastric cancer
    Tao Pan
    Zhijian Jin
    Zhenjia Yu
    Xiongyan Wu
    Xinyu Chang
    Zhiyuan Fan
    Fangyuan Li
    Xiaofeng Wang
    Zhen Li
    Quan Zhou
    Jianfang Li
    Bingya Liu
    Liping Su
    Gastric Cancer, 2020, 23 : 974 - 987
  • [20] VEGF promotes gastric cancer development by upregulating CRMP4
    Chen, Sile
    Zhang, Xinhua
    Peng, Jianjun
    Zhai, Ertao
    He, Yulong
    Wu, Hui
    Chen, Chuangqi
    Ma, Jinping
    Wang, Zhao
    Cai, Shirong
    ONCOTARGET, 2016, 7 (13) : 17074 - 17086
12345